CASP8-CFLAR Fusion FISH Probe
The CASP8-CFLAR Fusion FISH Probe is used to confirm a fusion of the CASP8 and CFLAR genes. The fusion of the CASP8 and CFLAR genes has been associated with Stomach Adenocarcinoma, and Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CASP8-CFLAR-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CASP8-CFLAR-20-RERE | 20 (40 μL) | 200 μL |
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| CASP8-CFLAR-20-REOR | 20 (40 μL) | 200 μL |
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| CASP8-CFLAR-20-REGO | 20 (40 μL) | 200 μL |
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| CASP8-CFLAR-20-REGR | 20 (40 μL) | 200 μL |
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| CASP8-CFLAR-20-REAQ | 20 (40 μL) | 200 μL |
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| CASP8-CFLAR-20-ORRE | 20 (40 μL) | 200 μL |
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| CASP8-CFLAR-20-OROR | 20 (40 μL) | 200 μL |
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| CASP8-CFLAR-20-ORGO | 20 (40 μL) | 200 μL |
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| CASP8-CFLAR-20-ORAQ | 20 (40 μL) | 200 μL |
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| CASP8-CFLAR-20-GORE | 20 (40 μL) | 200 μL |
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| CASP8-CFLAR-20-GOOR | 20 (40 μL) | 200 μL |
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| CASP8-CFLAR-20-GOGO | 20 (40 μL) | 200 μL |
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| CASP8-CFLAR-20-GOGR | 20 (40 μL) | 200 μL |
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| CASP8-CFLAR-20-GOAQ | 20 (40 μL) | 200 μL |
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| CASP8-CFLAR-20-GRRE | 20 (40 μL) | 200 μL |
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| CASP8-CFLAR-20-GROR | 20 (40 μL) | 200 μL |
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| CASP8-CFLAR-20-GRGO | 20 (40 μL) | 200 μL |
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| CASP8-CFLAR-20-GRGR | 20 (40 μL) | 200 μL |
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| CASP8-CFLAR-20-GRAQ | 20 (40 μL) | 200 μL |
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| CASP8-CFLAR-20-AQRE | 20 (40 μL) | 200 μL |
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| CASP8-CFLAR-20-AQOR | 20 (40 μL) | 200 μL |
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| CASP8-CFLAR-20-AQGO | 20 (40 μL) | 200 μL |
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| CASP8-CFLAR-20-AQGR | 20 (40 μL) | 200 μL |
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| CASP8-CFLAR-20-AQAQ | 20 (40 μL) | 200 μL |
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CASP8 Gene Summary
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined. [provided by RefSeq, Jul 2008]
Gene Name: Caspase 8
Chromosome: CHR2: 202098165 -202152434
Locus: 2q33.1
CFLAR Gene Summary
The protein encoded by this gene is a regulator of apoptosis and is structurally similar to caspase-8. However, the encoded protein lacks caspase activity and appears to be itself cleaved into two peptides by caspase-8. Several transcript variants encoding different isoforms have been found for this gene, and partial evidence for several more variants exists. [provided by RefSeq, Feb 2011]
Gene Name: CASP8 And FADD Like Apoptosis Regulator
Chromosome: CHR2: 201980876 -202037411
Locus: 2q33.1
Gene Diseases
The CASP8 CFLAR Fusion has been associated with the following diseases:
| Disease Name |
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| Stomach Adenocarcinoma |
| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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