CASP10-CFLAR Fusion FISH Probe
The CASP10-CFLAR Fusion FISH Probe is used to confirm a fusion of the CASP10 and CFLAR genes. The fusion of the CASP10 and CFLAR genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CASP10-CFLAR-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CASP10-CFLAR-20-RERE | 20 (40 μL) | 200 μL |
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| CASP10-CFLAR-20-REOR | 20 (40 μL) | 200 μL |
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| CASP10-CFLAR-20-REGO | 20 (40 μL) | 200 μL |
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| CASP10-CFLAR-20-REGR | 20 (40 μL) | 200 μL |
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| CASP10-CFLAR-20-REAQ | 20 (40 μL) | 200 μL |
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| CASP10-CFLAR-20-ORRE | 20 (40 μL) | 200 μL |
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| CASP10-CFLAR-20-OROR | 20 (40 μL) | 200 μL |
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| CASP10-CFLAR-20-ORGO | 20 (40 μL) | 200 μL |
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| CASP10-CFLAR-20-ORAQ | 20 (40 μL) | 200 μL |
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| CASP10-CFLAR-20-GORE | 20 (40 μL) | 200 μL |
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| CASP10-CFLAR-20-GOOR | 20 (40 μL) | 200 μL |
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| CASP10-CFLAR-20-GOGO | 20 (40 μL) | 200 μL |
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| CASP10-CFLAR-20-GOGR | 20 (40 μL) | 200 μL |
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| CASP10-CFLAR-20-GOAQ | 20 (40 μL) | 200 μL |
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| CASP10-CFLAR-20-GRRE | 20 (40 μL) | 200 μL |
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| CASP10-CFLAR-20-GROR | 20 (40 μL) | 200 μL |
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| CASP10-CFLAR-20-GRGO | 20 (40 μL) | 200 μL |
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| CASP10-CFLAR-20-GRGR | 20 (40 μL) | 200 μL |
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| CASP10-CFLAR-20-GRAQ | 20 (40 μL) | 200 μL |
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| CASP10-CFLAR-20-AQRE | 20 (40 μL) | 200 μL |
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| CASP10-CFLAR-20-AQOR | 20 (40 μL) | 200 μL |
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| CASP10-CFLAR-20-AQGO | 20 (40 μL) | 200 μL |
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| CASP10-CFLAR-20-AQGR | 20 (40 μL) | 200 μL |
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| CASP10-CFLAR-20-AQAQ | 20 (40 μL) | 200 μL |
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CASP10 Gene Summary
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 3 and 7, and the protein itself is processed by caspase 8. Mutations in this gene are associated with type IIA autoimmune lymphoproliferative syndrome, non-Hodgkin lymphoma and gastric cancer. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Apr 2011]
Gene Name: Caspase 10
Chromosome: CHR2: 202047620 -202094129
Locus: 2q33.1
CFLAR Gene Summary
The protein encoded by this gene is a regulator of apoptosis and is structurally similar to caspase-8. However, the encoded protein lacks caspase activity and appears to be itself cleaved into two peptides by caspase-8. Several transcript variants encoding different isoforms have been found for this gene, and partial evidence for several more variants exists. [provided by RefSeq, Feb 2011]
Gene Name: CASP8 And FADD Like Apoptosis Regulator
Chromosome: CHR2: 201980876 -202037411
Locus: 2q33.1
Gene Diseases
The CASP10 CFLAR Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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