CASC3-THRA Fusion FISH Probe
The CASC3-THRA Fusion FISH Probe is used to confirm a fusion of the CASC3 and THRA genes. The fusion of the CASC3 and THRA genes has been associated with Cholangiocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CASC3-THRA-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CASC3-THRA-20-RERE | 20 (40 μL) | 200 μL |
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| CASC3-THRA-20-REOR | 20 (40 μL) | 200 μL |
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| CASC3-THRA-20-REGO | 20 (40 μL) | 200 μL |
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| CASC3-THRA-20-REGR | 20 (40 μL) | 200 μL |
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| CASC3-THRA-20-REAQ | 20 (40 μL) | 200 μL |
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| CASC3-THRA-20-ORRE | 20 (40 μL) | 200 μL |
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| CASC3-THRA-20-OROR | 20 (40 μL) | 200 μL |
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| CASC3-THRA-20-ORGO | 20 (40 μL) | 200 μL |
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| CASC3-THRA-20-ORAQ | 20 (40 μL) | 200 μL |
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| CASC3-THRA-20-GORE | 20 (40 μL) | 200 μL |
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| CASC3-THRA-20-GOOR | 20 (40 μL) | 200 μL |
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| CASC3-THRA-20-GOGO | 20 (40 μL) | 200 μL |
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| CASC3-THRA-20-GOGR | 20 (40 μL) | 200 μL |
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| CASC3-THRA-20-GOAQ | 20 (40 μL) | 200 μL |
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| CASC3-THRA-20-GRRE | 20 (40 μL) | 200 μL |
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| CASC3-THRA-20-GROR | 20 (40 μL) | 200 μL |
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| CASC3-THRA-20-GRGO | 20 (40 μL) | 200 μL |
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| CASC3-THRA-20-GRGR | 20 (40 μL) | 200 μL |
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| CASC3-THRA-20-GRAQ | 20 (40 μL) | 200 μL |
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| CASC3-THRA-20-AQRE | 20 (40 μL) | 200 μL |
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| CASC3-THRA-20-AQOR | 20 (40 μL) | 200 μL |
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| CASC3-THRA-20-AQGO | 20 (40 μL) | 200 μL |
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| CASC3-THRA-20-AQGR | 20 (40 μL) | 200 μL |
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| CASC3-THRA-20-AQAQ | 20 (40 μL) | 200 μL |
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THRA Gene Summary
The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Gene Name: Thyroid Hormone Receptor, Alpha
Chromosome: CHR17: 38218445 -38250120
Locus: 17q21.1
CASC3 Gene Summary
The product of this gene is a core component of the exon junction complex (EJC), a protein complex that is deposited on spliced mRNAs at exon-exon junctions and functions in nonsense-mediated mRNA decay (NMD). The encoded protein binds RNA and interacts with two other EJC core components. It is predominantly located in the cytoplasm, but shuttles into the nucleus where it localizes to nuclear speckles. [provided by RefSeq, Jul 2008]
Gene Name: Cancer Susceptibility 3
Chromosome: CHR17: 38296506 -38328431
Locus: 17q21.1
Gene Diseases
The CASC3 THRA Fusion has been associated with the following diseases:
| Disease Name |
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| Cholangiocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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