CARS-OSBPL5 Fusion FISH Probe
The CARS-OSBPL5 Fusion FISH Probe is used to confirm a fusion of the CARS and OSBPL5 genes. The fusion of the CARS and OSBPL5 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CARS-OSBPL5-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CARS-OSBPL5-20-RERE | 20 (40 μL) | 200 μL |
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| CARS-OSBPL5-20-REOR | 20 (40 μL) | 200 μL |
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| CARS-OSBPL5-20-REGO | 20 (40 μL) | 200 μL |
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| CARS-OSBPL5-20-REGR | 20 (40 μL) | 200 μL |
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| CARS-OSBPL5-20-REAQ | 20 (40 μL) | 200 μL |
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| CARS-OSBPL5-20-ORRE | 20 (40 μL) | 200 μL |
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| CARS-OSBPL5-20-OROR | 20 (40 μL) | 200 μL |
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| CARS-OSBPL5-20-ORGO | 20 (40 μL) | 200 μL |
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| CARS-OSBPL5-20-ORAQ | 20 (40 μL) | 200 μL |
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| CARS-OSBPL5-20-GORE | 20 (40 μL) | 200 μL |
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| CARS-OSBPL5-20-GOOR | 20 (40 μL) | 200 μL |
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| CARS-OSBPL5-20-GOGO | 20 (40 μL) | 200 μL |
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| CARS-OSBPL5-20-GOGR | 20 (40 μL) | 200 μL |
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| CARS-OSBPL5-20-GOAQ | 20 (40 μL) | 200 μL |
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| CARS-OSBPL5-20-GRRE | 20 (40 μL) | 200 μL |
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| CARS-OSBPL5-20-GROR | 20 (40 μL) | 200 μL |
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| CARS-OSBPL5-20-GRGO | 20 (40 μL) | 200 μL |
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| CARS-OSBPL5-20-GRGR | 20 (40 μL) | 200 μL |
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| CARS-OSBPL5-20-GRAQ | 20 (40 μL) | 200 μL |
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| CARS-OSBPL5-20-AQRE | 20 (40 μL) | 200 μL |
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| CARS-OSBPL5-20-AQOR | 20 (40 μL) | 200 μL |
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| CARS-OSBPL5-20-AQGO | 20 (40 μL) | 200 μL |
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| CARS-OSBPL5-20-AQGR | 20 (40 μL) | 200 μL |
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| CARS-OSBPL5-20-AQAQ | 20 (40 μL) | 200 μL |
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CARS Gene Summary
This gene encodes a class 1 aminoacyl-tRNA synthetase, cysteinyl-tRNA synthetase. Each of the twenty aminoacyl-tRNA synthetases catalyzes the aminoacylation of a specific tRNA or tRNA isoaccepting family with the cognate amino acid. This gene is one of several located near the imprinted gene domain on chromosome 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian and breast cancers. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2010]
Gene Name: Cysteinyl-tRNA Synthetase
Chromosome: CHR11: 3022151 -3078681
Locus: 11p15.4
OSBPL5 Gene Summary
This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors that play a key role in the maintenance of cholesterol balance in the body. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. This gene has been shown to be imprinted, with preferential expression from the maternal allele only in placenta. Transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2010]
Gene Name: Oxysterol Binding Protein Like 5
Chromosome: CHR11: 3108345 -3186582
Locus: 11p15.4
Gene Diseases
The CARS OSBPL5 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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