CAPZB-CFL1 Fusion FISH Probe
The CAPZB-CFL1 Fusion FISH Probe is used to confirm a fusion of the CAPZB and CFL1 genes. The fusion of the CAPZB and CFL1 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CAPZB-CFL1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CAPZB-CFL1-20-RERE | 20 (40 μL) | 200 μL |
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| CAPZB-CFL1-20-REOR | 20 (40 μL) | 200 μL |
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| CAPZB-CFL1-20-REGO | 20 (40 μL) | 200 μL |
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| CAPZB-CFL1-20-REGR | 20 (40 μL) | 200 μL |
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| CAPZB-CFL1-20-REAQ | 20 (40 μL) | 200 μL |
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| CAPZB-CFL1-20-ORRE | 20 (40 μL) | 200 μL |
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| CAPZB-CFL1-20-OROR | 20 (40 μL) | 200 μL |
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| CAPZB-CFL1-20-ORGO | 20 (40 μL) | 200 μL |
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| CAPZB-CFL1-20-ORAQ | 20 (40 μL) | 200 μL |
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| CAPZB-CFL1-20-GORE | 20 (40 μL) | 200 μL |
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| CAPZB-CFL1-20-GOOR | 20 (40 μL) | 200 μL |
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| CAPZB-CFL1-20-GOGO | 20 (40 μL) | 200 μL |
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| CAPZB-CFL1-20-GOGR | 20 (40 μL) | 200 μL |
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| CAPZB-CFL1-20-GOAQ | 20 (40 μL) | 200 μL |
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| CAPZB-CFL1-20-GRRE | 20 (40 μL) | 200 μL |
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| CAPZB-CFL1-20-GROR | 20 (40 μL) | 200 μL |
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| CAPZB-CFL1-20-GRGO | 20 (40 μL) | 200 μL |
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| CAPZB-CFL1-20-GRGR | 20 (40 μL) | 200 μL |
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| CAPZB-CFL1-20-GRAQ | 20 (40 μL) | 200 μL |
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| CAPZB-CFL1-20-AQRE | 20 (40 μL) | 200 μL |
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| CAPZB-CFL1-20-AQOR | 20 (40 μL) | 200 μL |
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| CAPZB-CFL1-20-AQGO | 20 (40 μL) | 200 μL |
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| CAPZB-CFL1-20-AQGR | 20 (40 μL) | 200 μL |
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| CAPZB-CFL1-20-AQAQ | 20 (40 μL) | 200 μL |
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CAPZB Gene Summary
This gene encodes the beta subunit of the barbed-end actin binding protein, which belongs to the F-actin capping protein family. The capping protein is a heterodimeric actin capping protein that blocks actin filament assembly and disassembly at the fast growing (barbed) filament ends and functions in regulating actin filament dynamics as well as in stabilizing actin filament lengths in muscle and nonmuscle cells. A pseudogene of this gene is located on the long arm of chromosome 2. Multiple alternatively spliced transcript variants encoding different isoforms have been found.[provided by RefSeq, Aug 2013]
Gene Name: Capping Actin Protein Of Muscle Z-line Beta Subunit
Chromosome: CHR1: 19665266 -19812066
Locus: 1p36.13
CFL1 Gene Summary
The protein encoded by this gene can polymerize and depolymerize F-actin and G-actin in a pH-dependent manner. Increased phosphorylation of this protein by LIM kinase aids in Rho-induced reorganization of the actin cytoskeleton. Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. It is involved in the translocation of actin-cofilin complex from cytoplasm to nucleus.[supplied by OMIM, Apr 2004]
Gene Name: Cofilin 1
Chromosome: CHR11: 65622284 -65625804
Locus: 11q13.1
Gene Diseases
The CAPZB CFL1 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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