CAPN6-DCX Fusion FISH Probe
The CAPN6-DCX Fusion FISH Probe is used to confirm a fusion of the CAPN6 and DCX genes. The fusion of the CAPN6 and DCX genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CAPN6-DCX-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CAPN6-DCX-20-RERE | 20 (40 μL) | 200 μL |
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| CAPN6-DCX-20-REOR | 20 (40 μL) | 200 μL |
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| CAPN6-DCX-20-REGO | 20 (40 μL) | 200 μL |
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| CAPN6-DCX-20-REGR | 20 (40 μL) | 200 μL |
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| CAPN6-DCX-20-REAQ | 20 (40 μL) | 200 μL |
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| CAPN6-DCX-20-ORRE | 20 (40 μL) | 200 μL |
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| CAPN6-DCX-20-OROR | 20 (40 μL) | 200 μL |
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| CAPN6-DCX-20-ORGO | 20 (40 μL) | 200 μL |
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| CAPN6-DCX-20-ORAQ | 20 (40 μL) | 200 μL |
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| CAPN6-DCX-20-GORE | 20 (40 μL) | 200 μL |
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| CAPN6-DCX-20-GOOR | 20 (40 μL) | 200 μL |
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| CAPN6-DCX-20-GOGO | 20 (40 μL) | 200 μL |
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| CAPN6-DCX-20-GOGR | 20 (40 μL) | 200 μL |
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| CAPN6-DCX-20-GOAQ | 20 (40 μL) | 200 μL |
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| CAPN6-DCX-20-GRRE | 20 (40 μL) | 200 μL |
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| CAPN6-DCX-20-GROR | 20 (40 μL) | 200 μL |
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| CAPN6-DCX-20-GRGO | 20 (40 μL) | 200 μL |
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| CAPN6-DCX-20-GRGR | 20 (40 μL) | 200 μL |
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| CAPN6-DCX-20-GRAQ | 20 (40 μL) | 200 μL |
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| CAPN6-DCX-20-AQRE | 20 (40 μL) | 200 μL |
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| CAPN6-DCX-20-AQOR | 20 (40 μL) | 200 μL |
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| CAPN6-DCX-20-AQGO | 20 (40 μL) | 200 μL |
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| CAPN6-DCX-20-AQGR | 20 (40 μL) | 200 μL |
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| CAPN6-DCX-20-AQAQ | 20 (40 μL) | 200 μL |
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CAPN6 Gene Summary
Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. The protein encoded by this gene is highly expressed in the placenta. Its C-terminal region lacks any homology to the calmodulin-like domain of other calpains. The protein lacks critical active site residues and thus is suggested to be proteolytically inactive. The protein may play a role in tumor formation by inhibiting apoptosis and promoting angiogenesis. [provided by RefSeq, Nov 2009]
Gene Name: Calpain 6
Chromosome: CHRX: 110488326 -110513774
Locus: Xq23
DCX Gene Summary
This gene encodes a member of the doublecortin family. The protein encoded by this gene is a cytoplasmic protein and contains two doublecortin domains, which bind microtubules. In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The encoded protein appears to direct neuronal migration by regulating the organization and stability of microtubules. In addition, the encoded protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in this gene cause abnormal migration of neurons during development and disrupt the layering of the cortex, leading to epilepsy, cognitive disability, subcortical band heterotopia ("double cortex" syndrome) in females and lissencephaly ("smooth brain" syndrome) in males. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2010]
Gene Name: Doublecortin
Chromosome: CHRX: 110537006 -110655460
Locus: Xq23
Gene Diseases
The CAPN6 DCX Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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