CAMKK2-NR2C1 Fusion FISH Probe
The CAMKK2-NR2C1 Fusion FISH Probe is used to confirm a fusion of the CAMKK2 and NR2C1 genes. The fusion of the CAMKK2 and NR2C1 genes has been associated with Glioblastoma Multiforme. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CAMKK2-NR2C1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CAMKK2-NR2C1-20-RERE | 20 (40 μL) | 200 μL |
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| CAMKK2-NR2C1-20-REOR | 20 (40 μL) | 200 μL |
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| CAMKK2-NR2C1-20-REGO | 20 (40 μL) | 200 μL |
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| CAMKK2-NR2C1-20-REGR | 20 (40 μL) | 200 μL |
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| CAMKK2-NR2C1-20-REAQ | 20 (40 μL) | 200 μL |
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| CAMKK2-NR2C1-20-ORRE | 20 (40 μL) | 200 μL |
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| CAMKK2-NR2C1-20-OROR | 20 (40 μL) | 200 μL |
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| CAMKK2-NR2C1-20-ORGO | 20 (40 μL) | 200 μL |
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| CAMKK2-NR2C1-20-ORAQ | 20 (40 μL) | 200 μL |
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| CAMKK2-NR2C1-20-GORE | 20 (40 μL) | 200 μL |
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| CAMKK2-NR2C1-20-GOOR | 20 (40 μL) | 200 μL |
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| CAMKK2-NR2C1-20-GOGO | 20 (40 μL) | 200 μL |
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| CAMKK2-NR2C1-20-GOGR | 20 (40 μL) | 200 μL |
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| CAMKK2-NR2C1-20-GOAQ | 20 (40 μL) | 200 μL |
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| CAMKK2-NR2C1-20-GRRE | 20 (40 μL) | 200 μL |
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| CAMKK2-NR2C1-20-GROR | 20 (40 μL) | 200 μL |
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| CAMKK2-NR2C1-20-GRGO | 20 (40 μL) | 200 μL |
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| CAMKK2-NR2C1-20-GRGR | 20 (40 μL) | 200 μL |
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| CAMKK2-NR2C1-20-GRAQ | 20 (40 μL) | 200 μL |
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| CAMKK2-NR2C1-20-AQRE | 20 (40 μL) | 200 μL |
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| CAMKK2-NR2C1-20-AQOR | 20 (40 μL) | 200 μL |
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| CAMKK2-NR2C1-20-AQGO | 20 (40 μL) | 200 μL |
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| CAMKK2-NR2C1-20-AQGR | 20 (40 μL) | 200 μL |
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| CAMKK2-NR2C1-20-AQAQ | 20 (40 μL) | 200 μL |
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NR2C1 Gene Summary
This gene encodes a nuclear hormone receptor characterized by a highly conserved DNA binding domain (DBD), a variable hinge region, and a carboxy-terminal ligand binding domain (LBD) that is typical for all members of the steroid/thyroid hormone receptor superfamily. This protein also belongs to a large family of ligand-inducible transcription factors that regulate gene expression by binding to specific DNA sequences within promoters of target genes. Multiple alternatively spliced transcript variants have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]
Gene Name: Nuclear Receptor Subfamily 2 Group C Member 1
Chromosome: CHR12: 95414057 -95467404
Locus: 12q22
CAMKK2 Gene Summary
The product of this gene belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. The major isoform of this gene plays a role in the calcium/calmodulin-dependent (CaM) kinase cascade by phosphorylating the downstream kinases CaMK1 and CaMK4. Protein products of this gene also phosphorylate AMP-activated protein kinase (AMPK). This gene has its strongest expression in the brain and influences signalling cascades involved with learning and memory, neuronal differentiation and migration, neurite outgrowth, and synapse formation. Alternative splicing results in multiple transcript variants encoding distinct isoforms. The identified isoforms differ in their ability to undergo autophosphorylation and to phosphorylate downstream kinases. [provided by RefSeq, Jul 2012]
Gene Name: Calcium/calmodulin Dependent Protein Kinase Kinase 2
Chromosome: CHR12: 121675494 -121736111
Locus: 12q24.31
Gene Diseases
The CAMKK2 NR2C1 Fusion has been associated with the following diseases:
| Disease Name |
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| Glioblastoma Multiforme |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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