CAMKK2-KDM2B Fusion FISH Probe
The CAMKK2-KDM2B Fusion FISH Probe is used to confirm a fusion of the CAMKK2 and KDM2B genes. The fusion of the CAMKK2 and KDM2B genes has been associated with Uterine Corpus Endometrial Carcinoma, Prostate Adenocarcinoma, Prostate Adenocarcinoma, and Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CAMKK2-KDM2B-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CAMKK2-KDM2B-20-RERE | 20 (40 μL) | 200 μL |
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| CAMKK2-KDM2B-20-REOR | 20 (40 μL) | 200 μL |
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| CAMKK2-KDM2B-20-REGO | 20 (40 μL) | 200 μL |
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| CAMKK2-KDM2B-20-REGR | 20 (40 μL) | 200 μL |
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| CAMKK2-KDM2B-20-REAQ | 20 (40 μL) | 200 μL |
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| CAMKK2-KDM2B-20-ORRE | 20 (40 μL) | 200 μL |
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| CAMKK2-KDM2B-20-OROR | 20 (40 μL) | 200 μL |
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| CAMKK2-KDM2B-20-ORGO | 20 (40 μL) | 200 μL |
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| CAMKK2-KDM2B-20-ORAQ | 20 (40 μL) | 200 μL |
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| CAMKK2-KDM2B-20-GORE | 20 (40 μL) | 200 μL |
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| CAMKK2-KDM2B-20-GOOR | 20 (40 μL) | 200 μL |
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| CAMKK2-KDM2B-20-GOGO | 20 (40 μL) | 200 μL |
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| CAMKK2-KDM2B-20-GOGR | 20 (40 μL) | 200 μL |
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| CAMKK2-KDM2B-20-GOAQ | 20 (40 μL) | 200 μL |
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| CAMKK2-KDM2B-20-GRRE | 20 (40 μL) | 200 μL |
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| CAMKK2-KDM2B-20-GROR | 20 (40 μL) | 200 μL |
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| CAMKK2-KDM2B-20-GRGO | 20 (40 μL) | 200 μL |
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| CAMKK2-KDM2B-20-GRGR | 20 (40 μL) | 200 μL |
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| CAMKK2-KDM2B-20-GRAQ | 20 (40 μL) | 200 μL |
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| CAMKK2-KDM2B-20-AQRE | 20 (40 μL) | 200 μL |
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| CAMKK2-KDM2B-20-AQOR | 20 (40 μL) | 200 μL |
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| CAMKK2-KDM2B-20-AQGO | 20 (40 μL) | 200 μL |
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| CAMKK2-KDM2B-20-AQGR | 20 (40 μL) | 200 μL |
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| CAMKK2-KDM2B-20-AQAQ | 20 (40 μL) | 200 μL |
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CAMKK2 Gene Summary
The product of this gene belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. The major isoform of this gene plays a role in the calcium/calmodulin-dependent (CaM) kinase cascade by phosphorylating the downstream kinases CaMK1 and CaMK4. Protein products of this gene also phosphorylate AMP-activated protein kinase (AMPK). This gene has its strongest expression in the brain and influences signalling cascades involved with learning and memory, neuronal differentiation and migration, neurite outgrowth, and synapse formation. Alternative splicing results in multiple transcript variants encoding distinct isoforms. The identified isoforms differ in their ability to undergo autophosphorylation and to phosphorylate downstream kinases. [provided by RefSeq, Jul 2012]
Gene Name: Calcium/calmodulin Dependent Protein Kinase Kinase 2
Chromosome: CHR12: 121675494 -121736111
Locus: 12q24.31
KDM2B Gene Summary
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008]
Gene Name: Lysine Demethylase 2B
Chromosome: CHR12: 121866899 -122018920
Locus: 12q24.31
Gene Diseases
The CAMKK2 KDM2B Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Corpus Endometrial Carcinoma |
| Prostate Adenocarcinoma |
| Prostate Adenocarcinoma |
| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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