CAMKK2-DIP2B Fusion FISH Probe
The CAMKK2-DIP2B Fusion FISH Probe is used to confirm a fusion of the CAMKK2 and DIP2B genes. The fusion of the CAMKK2 and DIP2B genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CAMKK2-DIP2B-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CAMKK2-DIP2B-20-RERE | 20 (40 μL) | 200 μL |
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| CAMKK2-DIP2B-20-REOR | 20 (40 μL) | 200 μL |
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| CAMKK2-DIP2B-20-REGO | 20 (40 μL) | 200 μL |
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| CAMKK2-DIP2B-20-REGR | 20 (40 μL) | 200 μL |
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| CAMKK2-DIP2B-20-REAQ | 20 (40 μL) | 200 μL |
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| CAMKK2-DIP2B-20-ORRE | 20 (40 μL) | 200 μL |
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| CAMKK2-DIP2B-20-OROR | 20 (40 μL) | 200 μL |
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| CAMKK2-DIP2B-20-ORGO | 20 (40 μL) | 200 μL |
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| CAMKK2-DIP2B-20-ORAQ | 20 (40 μL) | 200 μL |
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| CAMKK2-DIP2B-20-GORE | 20 (40 μL) | 200 μL |
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| CAMKK2-DIP2B-20-GOOR | 20 (40 μL) | 200 μL |
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| CAMKK2-DIP2B-20-GOGO | 20 (40 μL) | 200 μL |
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| CAMKK2-DIP2B-20-GOGR | 20 (40 μL) | 200 μL |
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| CAMKK2-DIP2B-20-GOAQ | 20 (40 μL) | 200 μL |
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| CAMKK2-DIP2B-20-GRRE | 20 (40 μL) | 200 μL |
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| CAMKK2-DIP2B-20-GROR | 20 (40 μL) | 200 μL |
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| CAMKK2-DIP2B-20-GRGO | 20 (40 μL) | 200 μL |
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| CAMKK2-DIP2B-20-GRGR | 20 (40 μL) | 200 μL |
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| CAMKK2-DIP2B-20-GRAQ | 20 (40 μL) | 200 μL |
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| CAMKK2-DIP2B-20-AQRE | 20 (40 μL) | 200 μL |
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| CAMKK2-DIP2B-20-AQOR | 20 (40 μL) | 200 μL |
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| CAMKK2-DIP2B-20-AQGO | 20 (40 μL) | 200 μL |
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| CAMKK2-DIP2B-20-AQGR | 20 (40 μL) | 200 μL |
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| CAMKK2-DIP2B-20-AQAQ | 20 (40 μL) | 200 μL |
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CAMKK2 Gene Summary
The product of this gene belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. The major isoform of this gene plays a role in the calcium/calmodulin-dependent (CaM) kinase cascade by phosphorylating the downstream kinases CaMK1 and CaMK4. Protein products of this gene also phosphorylate AMP-activated protein kinase (AMPK). This gene has its strongest expression in the brain and influences signalling cascades involved with learning and memory, neuronal differentiation and migration, neurite outgrowth, and synapse formation. Alternative splicing results in multiple transcript variants encoding distinct isoforms. The identified isoforms differ in their ability to undergo autophosphorylation and to phosphorylate downstream kinases. [provided by RefSeq, Jul 2012]
Gene Name: Calcium/calmodulin Dependent Protein Kinase Kinase 2
Chromosome: CHR12: 121675494 -121736111
Locus: 12q24.31
DIP2B Gene Summary
This gene encodes a member of the disco-interacting protein homolog 2 protein family. The encoded protein contains a binding site for the transcriptional regulator DNA methyltransferase 1 associated protein 1 as well as AMP-binding sites. The presence of these sites suggests that the encoded protein may participate in DNA methylation. This gene is located near a folate-sensitive fragile site, and CGG-repeat expansion in the promoter of this gene which affects transcription has been detected in individuals containing this fragile site on chromosome 12. [provided by RefSeq, Aug 2011]
Gene Name: Disco Interacting Protein 2 Homolog B
Chromosome: CHR12: 50898767 -51142450
Locus: 12q13.12
Gene Diseases
The CAMKK2 DIP2B Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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