CAMKK2-ANAPC5 Fusion FISH Probe
The CAMKK2-ANAPC5 Fusion FISH Probe is used to confirm a fusion of the CAMKK2 and ANAPC5 genes. The fusion of the CAMKK2 and ANAPC5 genes has been associated with Liver Hepatocellular Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CAMKK2-ANAPC5-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CAMKK2-ANAPC5-20-RERE | 20 (40 μL) | 200 μL |
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| CAMKK2-ANAPC5-20-REOR | 20 (40 μL) | 200 μL |
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| CAMKK2-ANAPC5-20-REGO | 20 (40 μL) | 200 μL |
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| CAMKK2-ANAPC5-20-REGR | 20 (40 μL) | 200 μL |
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| CAMKK2-ANAPC5-20-REAQ | 20 (40 μL) | 200 μL |
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| CAMKK2-ANAPC5-20-ORRE | 20 (40 μL) | 200 μL |
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| CAMKK2-ANAPC5-20-OROR | 20 (40 μL) | 200 μL |
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| CAMKK2-ANAPC5-20-ORGO | 20 (40 μL) | 200 μL |
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| CAMKK2-ANAPC5-20-ORAQ | 20 (40 μL) | 200 μL |
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| CAMKK2-ANAPC5-20-GORE | 20 (40 μL) | 200 μL |
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| CAMKK2-ANAPC5-20-GOOR | 20 (40 μL) | 200 μL |
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| CAMKK2-ANAPC5-20-GOGO | 20 (40 μL) | 200 μL |
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| CAMKK2-ANAPC5-20-GOGR | 20 (40 μL) | 200 μL |
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| CAMKK2-ANAPC5-20-GOAQ | 20 (40 μL) | 200 μL |
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| CAMKK2-ANAPC5-20-GRRE | 20 (40 μL) | 200 μL |
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| CAMKK2-ANAPC5-20-GROR | 20 (40 μL) | 200 μL |
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| CAMKK2-ANAPC5-20-GRGO | 20 (40 μL) | 200 μL |
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| CAMKK2-ANAPC5-20-GRGR | 20 (40 μL) | 200 μL |
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| CAMKK2-ANAPC5-20-GRAQ | 20 (40 μL) | 200 μL |
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| CAMKK2-ANAPC5-20-AQRE | 20 (40 μL) | 200 μL |
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| CAMKK2-ANAPC5-20-AQOR | 20 (40 μL) | 200 μL |
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| CAMKK2-ANAPC5-20-AQGO | 20 (40 μL) | 200 μL |
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| CAMKK2-ANAPC5-20-AQGR | 20 (40 μL) | 200 μL |
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| CAMKK2-ANAPC5-20-AQAQ | 20 (40 μL) | 200 μL |
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CAMKK2 Gene Summary
The product of this gene belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. The major isoform of this gene plays a role in the calcium/calmodulin-dependent (CaM) kinase cascade by phosphorylating the downstream kinases CaMK1 and CaMK4. Protein products of this gene also phosphorylate AMP-activated protein kinase (AMPK). This gene has its strongest expression in the brain and influences signalling cascades involved with learning and memory, neuronal differentiation and migration, neurite outgrowth, and synapse formation. Alternative splicing results in multiple transcript variants encoding distinct isoforms. The identified isoforms differ in their ability to undergo autophosphorylation and to phosphorylate downstream kinases. [provided by RefSeq, Jul 2012]
Gene Name: Calcium/calmodulin Dependent Protein Kinase Kinase 2
Chromosome: CHR12: 121675494 -121736111
Locus: 12q24.31
ANAPC5 Gene Summary
This gene encodes a tetratricopeptide repeat-containing component of the anaphase promoting complex/cyclosome (APC/C), a large E3 ubiquitin ligase that controls cell cycle progression by targeting a number of cell cycle regulators such as B-type cyclins for 26S proteasome-mediated degradation through ubiquitination. The encoded protein is required for the proper ubiquitination function of APC/C and for the interaction of APC/C with transcription coactivators. It also interacts with polyA binding protein and represses internal ribosome entry site-mediated translation. Multiple transcript variants encoding different isoforms have been found for this gene. These differences cause translation initiation at a downstream AUG and result in a shorter protein (isoform b), compared to isoform a. [provided by RefSeq, Nov 2008]
Gene Name: Anaphase Promoting Complex Subunit 5
Chromosome: CHR12: 121746047 -121792012
Locus: 12q24.31
Gene Diseases
The CAMKK2 ANAPC5 Fusion has been associated with the following diseases:
| Disease Name |
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| Liver Hepatocellular Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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