CALM2-TTC7A Fusion FISH Probe
The CALM2-TTC7A Fusion FISH Probe is used to confirm a fusion of the CALM2 and TTC7A genes. The fusion of the CALM2 and TTC7A genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CALM2-TTC7A-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CALM2-TTC7A-20-RERE | 20 (40 μL) | 200 μL |
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| CALM2-TTC7A-20-REOR | 20 (40 μL) | 200 μL |
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| CALM2-TTC7A-20-REGO | 20 (40 μL) | 200 μL |
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| CALM2-TTC7A-20-REGR | 20 (40 μL) | 200 μL |
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| CALM2-TTC7A-20-REAQ | 20 (40 μL) | 200 μL |
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| CALM2-TTC7A-20-ORRE | 20 (40 μL) | 200 μL |
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| CALM2-TTC7A-20-OROR | 20 (40 μL) | 200 μL |
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| CALM2-TTC7A-20-ORGO | 20 (40 μL) | 200 μL |
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| CALM2-TTC7A-20-ORAQ | 20 (40 μL) | 200 μL |
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| CALM2-TTC7A-20-GORE | 20 (40 μL) | 200 μL |
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| CALM2-TTC7A-20-GOOR | 20 (40 μL) | 200 μL |
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| CALM2-TTC7A-20-GOGO | 20 (40 μL) | 200 μL |
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| CALM2-TTC7A-20-GOGR | 20 (40 μL) | 200 μL |
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| CALM2-TTC7A-20-GOAQ | 20 (40 μL) | 200 μL |
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| CALM2-TTC7A-20-GRRE | 20 (40 μL) | 200 μL |
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| CALM2-TTC7A-20-GROR | 20 (40 μL) | 200 μL |
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| CALM2-TTC7A-20-GRGO | 20 (40 μL) | 200 μL |
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| CALM2-TTC7A-20-GRGR | 20 (40 μL) | 200 μL |
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| CALM2-TTC7A-20-GRAQ | 20 (40 μL) | 200 μL |
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| CALM2-TTC7A-20-AQRE | 20 (40 μL) | 200 μL |
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| CALM2-TTC7A-20-AQOR | 20 (40 μL) | 200 μL |
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| CALM2-TTC7A-20-AQGO | 20 (40 μL) | 200 μL |
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| CALM2-TTC7A-20-AQGR | 20 (40 μL) | 200 μL |
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| CALM2-TTC7A-20-AQAQ | 20 (40 μL) | 200 μL |
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CALM2 Gene Summary
This gene is a member of the calmodulin gene family. There are three distinct calmodulin genes dispersed throughout the genome that encode the identical protein, but differ at the nucleotide level. Calmodulin is a calcium binding protein that plays a role in signaling pathways, cell cycle progression and proliferation. Several infants with severe forms of long-QT syndrome (LQTS) who displayed life-threatening ventricular arrhythmias together with delayed neurodevelopment and epilepsy were found to have mutations in either this gene or another member of the calmodulin gene family (PMID:23388215). Mutations in this gene have also been identified in patients with less severe forms of LQTS (PMID:24917665), while mutations in another calmodulin gene family member have been associated with catecholaminergic polymorphic ventricular tachycardia (CPVT)(PMID:23040497), a rare disorder thought to be the cause of a significant fraction of sudden cardiac deaths in young individuals. Pseudogenes of this gene are found on chromosomes 10, 13, and 17. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2015]
Gene Name: Calmodulin 2
Chromosome: CHR2: 47387220 -47403740
Locus: 2p21
TTC7A Gene Summary
This gene encodes a protein containing tetratricopeptide repeats. Mutations in this gene disrupt intestinal development and can cause early onset inflammatory bowel disease and intestinal atresia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]
Gene Name: Tetratricopeptide Repeat Domain 7A
Chromosome: CHR2: 47168312 -47303275
Locus: 2p21
Gene Diseases
The CALM2 TTC7A Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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