CACNB1-CDC6 Fusion FISH Probe
The CACNB1-CDC6 Fusion FISH Probe is used to confirm a fusion of the CACNB1 and CDC6 genes. The fusion of the CACNB1 and CDC6 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CACNB1-CDC6-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CACNB1-CDC6-20-RERE | 20 (40 μL) | 200 μL |
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| CACNB1-CDC6-20-REOR | 20 (40 μL) | 200 μL |
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| CACNB1-CDC6-20-REGO | 20 (40 μL) | 200 μL |
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| CACNB1-CDC6-20-REGR | 20 (40 μL) | 200 μL |
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| CACNB1-CDC6-20-REAQ | 20 (40 μL) | 200 μL |
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| CACNB1-CDC6-20-ORRE | 20 (40 μL) | 200 μL |
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| CACNB1-CDC6-20-OROR | 20 (40 μL) | 200 μL |
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| CACNB1-CDC6-20-ORGO | 20 (40 μL) | 200 μL |
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| CACNB1-CDC6-20-ORAQ | 20 (40 μL) | 200 μL |
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| CACNB1-CDC6-20-GORE | 20 (40 μL) | 200 μL |
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| CACNB1-CDC6-20-GOOR | 20 (40 μL) | 200 μL |
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| CACNB1-CDC6-20-GOGO | 20 (40 μL) | 200 μL |
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| CACNB1-CDC6-20-GOGR | 20 (40 μL) | 200 μL |
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| CACNB1-CDC6-20-GOAQ | 20 (40 μL) | 200 μL |
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| CACNB1-CDC6-20-GRRE | 20 (40 μL) | 200 μL |
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| CACNB1-CDC6-20-GROR | 20 (40 μL) | 200 μL |
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| CACNB1-CDC6-20-GRGO | 20 (40 μL) | 200 μL |
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| CACNB1-CDC6-20-GRGR | 20 (40 μL) | 200 μL |
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| CACNB1-CDC6-20-GRAQ | 20 (40 μL) | 200 μL |
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| CACNB1-CDC6-20-AQRE | 20 (40 μL) | 200 μL |
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| CACNB1-CDC6-20-AQOR | 20 (40 μL) | 200 μL |
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| CACNB1-CDC6-20-AQGO | 20 (40 μL) | 200 μL |
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| CACNB1-CDC6-20-AQGR | 20 (40 μL) | 200 μL |
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| CACNB1-CDC6-20-AQAQ | 20 (40 μL) | 200 μL |
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CACNB1 Gene Summary
The protein encoded by this gene belongs to the calcium channel beta subunit family. It plays an important role in the calcium channel by modulating G protein inhibition, increasing peak calcium current, controlling the alpha-1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified. [provided by RefSeq, Jul 2008]
Gene Name: Calcium Voltage-gated Channel Auxiliary Subunit Beta 1
Chromosome: CHR17: 37329708 -37353901
Locus: 17q12
CDC6 Gene Summary
The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the initiation of DNA replication. This protein functions as a regulator at the early steps of DNA replication. It localizes in cell nucleus during cell cyle G1, but translocates to the cytoplasm at the start of S phase. The subcellular translocation of this protein during cell cyle is regulated through its phosphorylation by Cdks. Transcription of this protein was reported to be regulated in response to mitogenic signals through transcriptional control mechanism involving E2F proteins. [provided by RefSeq, Jul 2008]
Gene Name: Cell Division Cycle 6
Chromosome: CHR17: 38444145 -38459413
Locus: 17q21.2
Gene Diseases
The CACNB1 CDC6 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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