CACNA2D2-THRSP Fusion FISH Probe
The CACNA2D2-THRSP Fusion FISH Probe is used to confirm a fusion of the CACNA2D2 and THRSP genes. The fusion of the CACNA2D2 and THRSP genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CACNA2D2-THRSP-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CACNA2D2-THRSP-20-RERE | 20 (40 μL) | 200 μL |
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| CACNA2D2-THRSP-20-REOR | 20 (40 μL) | 200 μL |
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| CACNA2D2-THRSP-20-REGO | 20 (40 μL) | 200 μL |
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| CACNA2D2-THRSP-20-REGR | 20 (40 μL) | 200 μL |
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| CACNA2D2-THRSP-20-REAQ | 20 (40 μL) | 200 μL |
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| CACNA2D2-THRSP-20-ORRE | 20 (40 μL) | 200 μL |
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| CACNA2D2-THRSP-20-OROR | 20 (40 μL) | 200 μL |
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| CACNA2D2-THRSP-20-ORGO | 20 (40 μL) | 200 μL |
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| CACNA2D2-THRSP-20-ORAQ | 20 (40 μL) | 200 μL |
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| CACNA2D2-THRSP-20-GORE | 20 (40 μL) | 200 μL |
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| CACNA2D2-THRSP-20-GOOR | 20 (40 μL) | 200 μL |
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| CACNA2D2-THRSP-20-GOGO | 20 (40 μL) | 200 μL |
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| CACNA2D2-THRSP-20-GOGR | 20 (40 μL) | 200 μL |
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| CACNA2D2-THRSP-20-GOAQ | 20 (40 μL) | 200 μL |
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| CACNA2D2-THRSP-20-GRRE | 20 (40 μL) | 200 μL |
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| CACNA2D2-THRSP-20-GROR | 20 (40 μL) | 200 μL |
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| CACNA2D2-THRSP-20-GRGO | 20 (40 μL) | 200 μL |
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| CACNA2D2-THRSP-20-GRGR | 20 (40 μL) | 200 μL |
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| CACNA2D2-THRSP-20-GRAQ | 20 (40 μL) | 200 μL |
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| CACNA2D2-THRSP-20-AQRE | 20 (40 μL) | 200 μL |
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| CACNA2D2-THRSP-20-AQOR | 20 (40 μL) | 200 μL |
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| CACNA2D2-THRSP-20-AQGO | 20 (40 μL) | 200 μL |
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| CACNA2D2-THRSP-20-AQGR | 20 (40 μL) | 200 μL |
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| CACNA2D2-THRSP-20-AQAQ | 20 (40 μL) | 200 μL |
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THRSP Gene Summary
The protein encoded by this gene is similar to the gene product of S14, a rat gene whose expression is limited to liver and adipose tissue and is controlled by nutritional and hormonal factors. This gene has been shown to be expressed in liver and adipocytes, particularly in lipomatous modules. It is also found to be expressed in lipogenic breast cancers, which suggests a role in controlling tumor lipid metabolism. [provided by RefSeq, Jul 2008]
Gene Name: Thyroid Hormone Responsive
Chromosome: CHR11: 77774906 -77779403
Locus: 11q14.1
CACNA2D2 Gene Summary
Calcium channels mediate the entry of calcium ions into the cell upon membrane polarization. This gene encodes the alpha-2/delta subunit of the voltage-dependent calcium channel complex. The complex consists of the main channel-forming subunit alpha-1, and auxiliary subunits alpha-2/delta, beta, and gamma. The auxiliary subunits function in the assembly and membrane localization of the complex, and modulate calcium currents and channel activation/inactivation kinetics. The subunit encoded by this gene undergoes post-translational cleavage to yield the extracellular alpha2 peptide and a membrane-anchored delta polypeptide. This subunit is a receptor for the antiepileptic drug, gabapentin. Mutations in this gene are associated with early infantile epileptic encephalopathy. Single nucleotide polymorphisms in this gene are correlated with increased sensitivity to opioid drugs. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2014]
Gene Name: Calcium Voltage-gated Channel Auxiliary Subunit Alpha2delta 2
Chromosome: CHR3: 50400230 -50540892
Locus: 3p21.31
Gene Diseases
The CACNA2D2 THRSP Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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