CACNA2D1-PTPN12 Fusion FISH Probe
The CACNA2D1-PTPN12 Fusion FISH Probe is used to confirm a fusion of the CACNA2D1 and PTPN12 genes. The fusion of the CACNA2D1 and PTPN12 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CACNA2D1-PTPN12-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CACNA2D1-PTPN12-20-RERE | 20 (40 μL) | 200 μL |
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| CACNA2D1-PTPN12-20-REOR | 20 (40 μL) | 200 μL |
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| CACNA2D1-PTPN12-20-REGO | 20 (40 μL) | 200 μL |
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| CACNA2D1-PTPN12-20-REGR | 20 (40 μL) | 200 μL |
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| CACNA2D1-PTPN12-20-REAQ | 20 (40 μL) | 200 μL |
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| CACNA2D1-PTPN12-20-ORRE | 20 (40 μL) | 200 μL |
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| CACNA2D1-PTPN12-20-OROR | 20 (40 μL) | 200 μL |
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| CACNA2D1-PTPN12-20-ORGO | 20 (40 μL) | 200 μL |
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| CACNA2D1-PTPN12-20-ORAQ | 20 (40 μL) | 200 μL |
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| CACNA2D1-PTPN12-20-GORE | 20 (40 μL) | 200 μL |
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| CACNA2D1-PTPN12-20-GOOR | 20 (40 μL) | 200 μL |
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| CACNA2D1-PTPN12-20-GOGO | 20 (40 μL) | 200 μL |
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| CACNA2D1-PTPN12-20-GOGR | 20 (40 μL) | 200 μL |
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| CACNA2D1-PTPN12-20-GOAQ | 20 (40 μL) | 200 μL |
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| CACNA2D1-PTPN12-20-GRRE | 20 (40 μL) | 200 μL |
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| CACNA2D1-PTPN12-20-GROR | 20 (40 μL) | 200 μL |
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| CACNA2D1-PTPN12-20-GRGO | 20 (40 μL) | 200 μL |
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| CACNA2D1-PTPN12-20-GRGR | 20 (40 μL) | 200 μL |
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| CACNA2D1-PTPN12-20-GRAQ | 20 (40 μL) | 200 μL |
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| CACNA2D1-PTPN12-20-AQRE | 20 (40 μL) | 200 μL |
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| CACNA2D1-PTPN12-20-AQOR | 20 (40 μL) | 200 μL |
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| CACNA2D1-PTPN12-20-AQGO | 20 (40 μL) | 200 μL |
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| CACNA2D1-PTPN12-20-AQGR | 20 (40 μL) | 200 μL |
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| CACNA2D1-PTPN12-20-AQAQ | 20 (40 μL) | 200 μL |
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CACNA2D1 Gene Summary
The preproprotein encoded by this gene is cleaved into multiple chains that comprise the alpha-2 and delta subunits of the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. Mutations in this gene can cause cardiac deficiencies, including Brugada syndrome and short QT syndrome. Alternate splicing results in multiple transcript variants, some of which may lack the delta subunit portion. [provided by RefSeq, Nov 2014]
Gene Name: Calcium Voltage-gated Channel Auxiliary Subunit Alpha2delta 1
Chromosome: CHR7: 81579417 -82073031
Locus: 7q21.11
PTPN12 Gene Summary
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains a C-terminal PEST motif, which serves as a protein-protein interaction domain, and may regulate protein intracellular half-life. This PTP was found to bind and dephosphorylate the product of the oncogene c-ABL and thus may play a role in oncogenesis. This PTP was also shown to interact with, and dephosphorylate, various products related to cytoskeletal structure and cell adhesion, such as p130 (Cas), CAKbeta/PTK2B, PSTPIP1, and paxillin. This suggests it has a regulatory role in controlling cell shape and mobility. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008]
Gene Name: Protein Tyrosine Phosphatase, Non-receptor Type 12
Chromosome: CHR7: 77166772 -77269388
Locus: 7q11.23
Gene Diseases
The CACNA2D1 PTPN12 Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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