CACNA1D-GNL3 Fusion FISH Probe
The CACNA1D-GNL3 Fusion FISH Probe is used to confirm a fusion of the CACNA1D and GNL3 genes. The fusion of the CACNA1D and GNL3 genes has been associated with Esophageal Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CACNA1D-GNL3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CACNA1D-GNL3-20-RERE | 20 (40 μL) | 200 μL |
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| CACNA1D-GNL3-20-REOR | 20 (40 μL) | 200 μL |
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| CACNA1D-GNL3-20-REGO | 20 (40 μL) | 200 μL |
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| CACNA1D-GNL3-20-REGR | 20 (40 μL) | 200 μL |
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| CACNA1D-GNL3-20-REAQ | 20 (40 μL) | 200 μL |
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| CACNA1D-GNL3-20-ORRE | 20 (40 μL) | 200 μL |
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| CACNA1D-GNL3-20-OROR | 20 (40 μL) | 200 μL |
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| CACNA1D-GNL3-20-ORGO | 20 (40 μL) | 200 μL |
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| CACNA1D-GNL3-20-ORAQ | 20 (40 μL) | 200 μL |
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| CACNA1D-GNL3-20-GORE | 20 (40 μL) | 200 μL |
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| CACNA1D-GNL3-20-GOOR | 20 (40 μL) | 200 μL |
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| CACNA1D-GNL3-20-GOGO | 20 (40 μL) | 200 μL |
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| CACNA1D-GNL3-20-GOGR | 20 (40 μL) | 200 μL |
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| CACNA1D-GNL3-20-GOAQ | 20 (40 μL) | 200 μL |
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| CACNA1D-GNL3-20-GRRE | 20 (40 μL) | 200 μL |
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| CACNA1D-GNL3-20-GROR | 20 (40 μL) | 200 μL |
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| CACNA1D-GNL3-20-GRGO | 20 (40 μL) | 200 μL |
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| CACNA1D-GNL3-20-GRGR | 20 (40 μL) | 200 μL |
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| CACNA1D-GNL3-20-GRAQ | 20 (40 μL) | 200 μL |
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| CACNA1D-GNL3-20-AQRE | 20 (40 μL) | 200 μL |
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| CACNA1D-GNL3-20-AQOR | 20 (40 μL) | 200 μL |
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| CACNA1D-GNL3-20-AQGO | 20 (40 μL) | 200 μL |
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| CACNA1D-GNL3-20-AQGR | 20 (40 μL) | 200 μL |
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| CACNA1D-GNL3-20-AQAQ | 20 (40 μL) | 200 μL |
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CACNA1D Gene Summary
Voltage-dependent calcium channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, and gene expression. Calcium channels are multisubunit complexes composed of alpha-1, beta, alpha-2/delta, and gamma subunits. The channel activity is directed by the pore-forming alpha-1 subunit, whereas the others act as auxiliary subunits regulating this activity. The distinctive properties of the calcium channel types are related primarily to the expression of a variety of alpha-1 isoforms, namely alpha-1A, B, C, D, E, and S. This gene encodes the alpha-1D subunit. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012]
Gene Name: Calcium Voltage-gated Channel Subunit Alpha1 D
Chromosome: CHR3: 53529030 -53846492
Locus: 3p21.1
GNL3 Gene Summary
The protein encoded by this gene may interact with p53 and may be involved in tumorigenesis. The encoded protein also appears to be important for stem cell proliferation. This protein is found in both the nucleus and nucleolus. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]
Gene Name: G Protein Nucleolar 3
Chromosome: CHR3: 52719935 -52728510
Locus: 3p21.1
Gene Diseases
The CACNA1D GNL3 Fusion has been associated with the following diseases:
| Disease Name |
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| Esophageal Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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