CACNA1C-WWP2 Fusion FISH Probe
The CACNA1C-WWP2 Fusion FISH Probe is used to confirm a fusion of the CACNA1C and WWP2 genes. The fusion of the CACNA1C and WWP2 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CACNA1C-WWP2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CACNA1C-WWP2-20-RERE | 20 (40 μL) | 200 μL |
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| CACNA1C-WWP2-20-REOR | 20 (40 μL) | 200 μL |
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| CACNA1C-WWP2-20-REGO | 20 (40 μL) | 200 μL |
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| CACNA1C-WWP2-20-REGR | 20 (40 μL) | 200 μL |
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| CACNA1C-WWP2-20-REAQ | 20 (40 μL) | 200 μL |
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| CACNA1C-WWP2-20-ORRE | 20 (40 μL) | 200 μL |
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| CACNA1C-WWP2-20-OROR | 20 (40 μL) | 200 μL |
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| CACNA1C-WWP2-20-ORGO | 20 (40 μL) | 200 μL |
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| CACNA1C-WWP2-20-ORAQ | 20 (40 μL) | 200 μL |
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| CACNA1C-WWP2-20-GORE | 20 (40 μL) | 200 μL |
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| CACNA1C-WWP2-20-GOOR | 20 (40 μL) | 200 μL |
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| CACNA1C-WWP2-20-GOGO | 20 (40 μL) | 200 μL |
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| CACNA1C-WWP2-20-GOGR | 20 (40 μL) | 200 μL |
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| CACNA1C-WWP2-20-GOAQ | 20 (40 μL) | 200 μL |
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| CACNA1C-WWP2-20-GRRE | 20 (40 μL) | 200 μL |
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| CACNA1C-WWP2-20-GROR | 20 (40 μL) | 200 μL |
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| CACNA1C-WWP2-20-GRGO | 20 (40 μL) | 200 μL |
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| CACNA1C-WWP2-20-GRGR | 20 (40 μL) | 200 μL |
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| CACNA1C-WWP2-20-GRAQ | 20 (40 μL) | 200 μL |
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| CACNA1C-WWP2-20-AQRE | 20 (40 μL) | 200 μL |
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| CACNA1C-WWP2-20-AQOR | 20 (40 μL) | 200 μL |
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| CACNA1C-WWP2-20-AQGO | 20 (40 μL) | 200 μL |
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| CACNA1C-WWP2-20-AQGR | 20 (40 μL) | 200 μL |
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| CACNA1C-WWP2-20-AQAQ | 20 (40 μL) | 200 μL |
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CACNA1C Gene Summary
This gene encodes an alpha-1 subunit of a voltage-dependent calcium channel. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. The alpha-1 subunit consists of 24 transmembrane segments and forms the pore through which ions pass into the cell. The calcium channel consists of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. There are multiple isoforms of each of these proteins, either encoded by different genes or the result of alternative splicing of transcripts. The protein encoded by this gene binds to and is inhibited by dihydropyridine. Alternative splicing results in many transcript variants encoding different proteins. Some of the predicted proteins may not produce functional ion channel subunits. [provided by RefSeq, Oct 2012]
Gene Name: Calcium Voltage-gated Channel Subunit Alpha1 C
Chromosome: CHR12: 2162415 -2807115
Locus: 12p13.33
WWP2 Gene Summary
This gene encodes a member of the Nedd4 family of E3 ligases, which play an important role in protein ubiquitination. The encoded protein contains four WW domains and may play a role in multiple processes including chondrogenesis and the regulation of oncogenic signaling pathways via interactions with Smad proteins and the tumor suppressor PTEN. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 10. [provided by RefSeq, Jul 2012]
Gene Name: WW Domain Containing E3 Ubiquitin Protein Ligase 2
Chromosome: CHR16: 69796273 -69975643
Locus: 16q22.1
Gene Diseases
The CACNA1C WWP2 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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