CABLES1-RBBP8 Fusion FISH Probe
The CABLES1-RBBP8 Fusion FISH Probe is used to confirm a fusion of the CABLES1 and RBBP8 genes. The fusion of the CABLES1 and RBBP8 genes has been associated with Breast Invasive Carcinoma, and Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CABLES1-RBBP8-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CABLES1-RBBP8-20-RERE | 20 (40 μL) | 200 μL |
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| CABLES1-RBBP8-20-REOR | 20 (40 μL) | 200 μL |
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| CABLES1-RBBP8-20-REGO | 20 (40 μL) | 200 μL |
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| CABLES1-RBBP8-20-REGR | 20 (40 μL) | 200 μL |
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| CABLES1-RBBP8-20-REAQ | 20 (40 μL) | 200 μL |
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| CABLES1-RBBP8-20-ORRE | 20 (40 μL) | 200 μL |
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| CABLES1-RBBP8-20-OROR | 20 (40 μL) | 200 μL |
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| CABLES1-RBBP8-20-ORGO | 20 (40 μL) | 200 μL |
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| CABLES1-RBBP8-20-ORAQ | 20 (40 μL) | 200 μL |
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| CABLES1-RBBP8-20-GORE | 20 (40 μL) | 200 μL |
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| CABLES1-RBBP8-20-GOOR | 20 (40 μL) | 200 μL |
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| CABLES1-RBBP8-20-GOGO | 20 (40 μL) | 200 μL |
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| CABLES1-RBBP8-20-GOGR | 20 (40 μL) | 200 μL |
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| CABLES1-RBBP8-20-GOAQ | 20 (40 μL) | 200 μL |
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| CABLES1-RBBP8-20-GRRE | 20 (40 μL) | 200 μL |
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| CABLES1-RBBP8-20-GROR | 20 (40 μL) | 200 μL |
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| CABLES1-RBBP8-20-GRGO | 20 (40 μL) | 200 μL |
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| CABLES1-RBBP8-20-GRGR | 20 (40 μL) | 200 μL |
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| CABLES1-RBBP8-20-GRAQ | 20 (40 μL) | 200 μL |
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| CABLES1-RBBP8-20-AQRE | 20 (40 μL) | 200 μL |
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| CABLES1-RBBP8-20-AQOR | 20 (40 μL) | 200 μL |
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| CABLES1-RBBP8-20-AQGO | 20 (40 μL) | 200 μL |
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| CABLES1-RBBP8-20-AQGR | 20 (40 μL) | 200 μL |
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| CABLES1-RBBP8-20-AQAQ | 20 (40 μL) | 200 μL |
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RBBP8 Gene Summary
The protein encoded by this gene is a ubiquitously expressed nuclear protein. It is found among several proteins that bind directly to retinoblastoma protein, which regulates cell proliferation. This protein complexes with transcriptional co-repressor CTBP. It is also associated with BRCA1 and is thought to modulate the functions of BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control. It is suggested that this gene may itself be a tumor suppressor acting in the same pathway as BRCA1. Three transcript variants encoding two different isoforms have been found for this gene. More transcript variants exist, but their full-length natures have not been determined. [provided by RefSeq, Jul 2008]
Gene Name: RB Binding Protein 8, Endonuclease
Chromosome: CHR18: 20513294 -20606449
Locus: 18q11.2
CABLES1 Gene Summary
This gene encodes a protein involved in regulation of the cell cycle through interactions with several cyclin-dependent kinases. One study (PMID: 16177568) reported aberrant splicing of transcripts from this gene which results in removal of the cyclin binding domain only in human cancer cells, and reduction in gene expression was shown in colorectal cancers (PMID: 17982127).Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Gene Name: Cdk5 And Abl Enzyme Substrate 1
Chromosome: CHR18: 20714527 -20840434
Locus: 18q11.2
Gene Diseases
The CABLES1 RBBP8 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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