CABLES1-FTO Fusion FISH Probe
The CABLES1-FTO Fusion FISH Probe is used to confirm a fusion of the CABLES1 and FTO genes. The fusion of the CABLES1 and FTO genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CABLES1-FTO-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CABLES1-FTO-20-RERE | 20 (40 μL) | 200 μL |
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| CABLES1-FTO-20-REOR | 20 (40 μL) | 200 μL |
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| CABLES1-FTO-20-REGO | 20 (40 μL) | 200 μL |
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| CABLES1-FTO-20-REGR | 20 (40 μL) | 200 μL |
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| CABLES1-FTO-20-REAQ | 20 (40 μL) | 200 μL |
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| CABLES1-FTO-20-ORRE | 20 (40 μL) | 200 μL |
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| CABLES1-FTO-20-OROR | 20 (40 μL) | 200 μL |
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| CABLES1-FTO-20-ORGO | 20 (40 μL) | 200 μL |
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| CABLES1-FTO-20-ORAQ | 20 (40 μL) | 200 μL |
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| CABLES1-FTO-20-GORE | 20 (40 μL) | 200 μL |
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| CABLES1-FTO-20-GOOR | 20 (40 μL) | 200 μL |
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| CABLES1-FTO-20-GOGO | 20 (40 μL) | 200 μL |
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| CABLES1-FTO-20-GOGR | 20 (40 μL) | 200 μL |
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| CABLES1-FTO-20-GOAQ | 20 (40 μL) | 200 μL |
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| CABLES1-FTO-20-GRRE | 20 (40 μL) | 200 μL |
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| CABLES1-FTO-20-GROR | 20 (40 μL) | 200 μL |
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| CABLES1-FTO-20-GRGO | 20 (40 μL) | 200 μL |
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| CABLES1-FTO-20-GRGR | 20 (40 μL) | 200 μL |
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| CABLES1-FTO-20-GRAQ | 20 (40 μL) | 200 μL |
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| CABLES1-FTO-20-AQRE | 20 (40 μL) | 200 μL |
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| CABLES1-FTO-20-AQOR | 20 (40 μL) | 200 μL |
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| CABLES1-FTO-20-AQGO | 20 (40 μL) | 200 μL |
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| CABLES1-FTO-20-AQGR | 20 (40 μL) | 200 μL |
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| CABLES1-FTO-20-AQAQ | 20 (40 μL) | 200 μL |
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FTO Gene Summary
This gene is a nuclear protein of the AlkB related non-haem iron and 2-oxoglutarate-dependent oxygenase superfamily but the exact physiological function of this gene is not known. Other non-heme iron enzymes function to reverse alkylated DNA and RNA damage by oxidative demethylation. Studies in mice and humans indicate a role in nervous and cardiovascular systems and a strong association with body mass index, obesity risk, and type 2 diabetes. [provided by RefSeq, Jul 2011]
Gene Name: FTO, Alpha-ketoglutarate Dependent Dioxygenase
Chromosome: CHR16: 53737874 -54148379
Locus: 16q12.2
CABLES1 Gene Summary
This gene encodes a protein involved in regulation of the cell cycle through interactions with several cyclin-dependent kinases. One study (PMID: 16177568) reported aberrant splicing of transcripts from this gene which results in removal of the cyclin binding domain only in human cancer cells, and reduction in gene expression was shown in colorectal cancers (PMID: 17982127).Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Gene Name: Cdk5 And Abl Enzyme Substrate 1
Chromosome: CHR18: 20714527 -20840434
Locus: 18q11.2
Gene Diseases
The CABLES1 FTO Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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