CA13-E2F5 Fusion FISH Probe
The CA13-E2F5 Fusion FISH Probe is used to confirm a fusion of the CA13 and E2F5 genes. The fusion of the CA13 and E2F5 genes has been associated with Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| CA13-E2F5-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| CA13-E2F5-20-RERE | 20 (40 μL) | 200 μL |
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| CA13-E2F5-20-REOR | 20 (40 μL) | 200 μL |
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| CA13-E2F5-20-REGO | 20 (40 μL) | 200 μL |
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| CA13-E2F5-20-REGR | 20 (40 μL) | 200 μL |
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| CA13-E2F5-20-REAQ | 20 (40 μL) | 200 μL |
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| CA13-E2F5-20-ORRE | 20 (40 μL) | 200 μL |
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| CA13-E2F5-20-OROR | 20 (40 μL) | 200 μL |
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| CA13-E2F5-20-ORGO | 20 (40 μL) | 200 μL |
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| CA13-E2F5-20-ORAQ | 20 (40 μL) | 200 μL |
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| CA13-E2F5-20-GORE | 20 (40 μL) | 200 μL |
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| CA13-E2F5-20-GOOR | 20 (40 μL) | 200 μL |
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| CA13-E2F5-20-GOGO | 20 (40 μL) | 200 μL |
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| CA13-E2F5-20-GOGR | 20 (40 μL) | 200 μL |
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| CA13-E2F5-20-GOAQ | 20 (40 μL) | 200 μL |
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| CA13-E2F5-20-GRRE | 20 (40 μL) | 200 μL |
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| CA13-E2F5-20-GROR | 20 (40 μL) | 200 μL |
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| CA13-E2F5-20-GRGO | 20 (40 μL) | 200 μL |
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| CA13-E2F5-20-GRGR | 20 (40 μL) | 200 μL |
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| CA13-E2F5-20-GRAQ | 20 (40 μL) | 200 μL |
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| CA13-E2F5-20-AQRE | 20 (40 μL) | 200 μL |
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| CA13-E2F5-20-AQOR | 20 (40 μL) | 200 μL |
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| CA13-E2F5-20-AQGO | 20 (40 μL) | 200 μL |
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| CA13-E2F5-20-AQGR | 20 (40 μL) | 200 μL |
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| CA13-E2F5-20-AQAQ | 20 (40 μL) | 200 μL |
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E2F5 Gene Summary
The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionarily conserved domains that are present in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein is differentially phosphorylated and is expressed in a wide variety of human tissues. It has higher identity to E2F4 than to other family members. Both this protein and E2F4 interact with tumor suppressor proteins p130 and p107, but not with pRB. Alternative splicing results in multiple variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Name: E2F Transcription Factor 5
Chromosome: CHR8: 86089618 -86126753
Locus: 8q21.2
CA13 Gene Summary
Carbonic anhydrases (CAs) are a family of zinc metalloenzymes. For background information on the CA family, see MIM 114800.[supplied by OMIM, Mar 2008]
Gene Name: Carbonic Anhydrase 13
Chromosome: CHR8: 86157715 -86196302
Locus: 8q21.2
Gene Diseases
The CA13 E2F5 Fusion has been associated with the following diseases:
| Disease Name |
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| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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