C8ORF34-MET Fusion FISH Probe
The C8ORF34-MET Fusion FISH Probe is used to confirm a fusion of the C8ORF34 and MET genes. The fusion of the C8ORF34 and MET genes has been associated with Kidney Renal Papillary Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| C8ORF34-MET-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| C8ORF34-MET-20-RERE | 20 (40 μL) | 200 μL |
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| C8ORF34-MET-20-REOR | 20 (40 μL) | 200 μL |
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| C8ORF34-MET-20-REGO | 20 (40 μL) | 200 μL |
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| C8ORF34-MET-20-REGR | 20 (40 μL) | 200 μL |
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| C8ORF34-MET-20-REAQ | 20 (40 μL) | 200 μL |
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| C8ORF34-MET-20-ORRE | 20 (40 μL) | 200 μL |
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| C8ORF34-MET-20-OROR | 20 (40 μL) | 200 μL |
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| C8ORF34-MET-20-ORGO | 20 (40 μL) | 200 μL |
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| C8ORF34-MET-20-ORAQ | 20 (40 μL) | 200 μL |
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| C8ORF34-MET-20-GORE | 20 (40 μL) | 200 μL |
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| C8ORF34-MET-20-GOOR | 20 (40 μL) | 200 μL |
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| C8ORF34-MET-20-GOGO | 20 (40 μL) | 200 μL |
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| C8ORF34-MET-20-GOGR | 20 (40 μL) | 200 μL |
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| C8ORF34-MET-20-GOAQ | 20 (40 μL) | 200 μL |
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| C8ORF34-MET-20-GRRE | 20 (40 μL) | 200 μL |
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| C8ORF34-MET-20-GROR | 20 (40 μL) | 200 μL |
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| C8ORF34-MET-20-GRGO | 20 (40 μL) | 200 μL |
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| C8ORF34-MET-20-GRGR | 20 (40 μL) | 200 μL |
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| C8ORF34-MET-20-GRAQ | 20 (40 μL) | 200 μL |
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| C8ORF34-MET-20-AQRE | 20 (40 μL) | 200 μL |
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| C8ORF34-MET-20-AQOR | 20 (40 μL) | 200 μL |
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| C8ORF34-MET-20-AQGO | 20 (40 μL) | 200 μL |
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| C8ORF34-MET-20-AQGR | 20 (40 μL) | 200 μL |
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| C8ORF34-MET-20-AQAQ | 20 (40 μL) | 200 μL |
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MET Gene Summary
This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that are linked via disulfide bonds to form the mature receptor. Further processing of the beta subunit results in the formation of the M10 peptide, which has been shown to reduce lung fibrosis. Binding of its ligand, hepatocyte growth factor, induces dimerization and activation of the receptor, which plays a role in cellular survival, embryogenesis, and cellular migration and invasion. Mutations in this gene are associated with papillary renal cell carcinoma, hepatocellular carcinoma, and various head and neck cancers. Amplification and overexpression of this gene are also associated with multiple human cancers. [provided by RefSeq, May 2016]
Gene Name: MET Proto-oncogene, Receptor Tyrosine Kinase
Chromosome: CHR7: 116312458 -116438440
Locus: 7q31.2
C8orf34 Gene Summary
This gene encodes a protein that is related to the cyclic AMP dependent protein kinase regulators. Naturally occurring mutations in this gene are associated with an increased risk for severe toxicities, such as diarrhea and neutropenia, in patients undergoing chemotherapeutic treatment. [provided by RefSeq, Mar 2017]
Gene Name: Chromosome 8 Open Reading Frame 34
Chromosome: CHR8: 69242956 -69731258
Locus: 8q13.2
Gene Diseases
The C8ORF34 MET Fusion has been associated with the following diseases:
| Disease Name |
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| Kidney Renal Papillary Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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