C5-SEMA4D Fusion FISH Probe
The C5-SEMA4D Fusion FISH Probe is used to confirm a fusion of the C5 and SEMA4D genes. The fusion of the C5 and SEMA4D genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| C5-SEMA4D-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| C5-SEMA4D-20-RERE | 20 (40 μL) | 200 μL |
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| C5-SEMA4D-20-REOR | 20 (40 μL) | 200 μL |
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| C5-SEMA4D-20-REGO | 20 (40 μL) | 200 μL |
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| C5-SEMA4D-20-REGR | 20 (40 μL) | 200 μL |
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| C5-SEMA4D-20-REAQ | 20 (40 μL) | 200 μL |
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| C5-SEMA4D-20-ORRE | 20 (40 μL) | 200 μL |
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| C5-SEMA4D-20-OROR | 20 (40 μL) | 200 μL |
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| C5-SEMA4D-20-ORGO | 20 (40 μL) | 200 μL |
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| C5-SEMA4D-20-ORAQ | 20 (40 μL) | 200 μL |
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| C5-SEMA4D-20-GORE | 20 (40 μL) | 200 μL |
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| C5-SEMA4D-20-GOOR | 20 (40 μL) | 200 μL |
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| C5-SEMA4D-20-GOGO | 20 (40 μL) | 200 μL |
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| C5-SEMA4D-20-GOGR | 20 (40 μL) | 200 μL |
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| C5-SEMA4D-20-GOAQ | 20 (40 μL) | 200 μL |
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| C5-SEMA4D-20-GRRE | 20 (40 μL) | 200 μL |
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| C5-SEMA4D-20-GROR | 20 (40 μL) | 200 μL |
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| C5-SEMA4D-20-GRGO | 20 (40 μL) | 200 μL |
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| C5-SEMA4D-20-GRGR | 20 (40 μL) | 200 μL |
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| C5-SEMA4D-20-GRAQ | 20 (40 μL) | 200 μL |
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| C5-SEMA4D-20-AQRE | 20 (40 μL) | 200 μL |
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| C5-SEMA4D-20-AQOR | 20 (40 μL) | 200 μL |
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| C5-SEMA4D-20-AQGO | 20 (40 μL) | 200 μL |
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| C5-SEMA4D-20-AQGR | 20 (40 μL) | 200 μL |
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| C5-SEMA4D-20-AQAQ | 20 (40 μL) | 200 μL |
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C5 Gene Summary
This gene encodes a component of the complement system, a part of the innate immune system that plays an important role in inflammation, host homeostasis, and host defense against pathogens. The encoded preproprotein is proteolytically processed to generate multiple protein products, including the C5 alpha chain, C5 beta chain, C5a anaphylatoxin and C5b. The C5 protein is comprised of the C5 alpha and beta chains, which are linked by a disulfide bridge. Cleavage of the alpha chain by a convertase enzyme results in the formation of the C5a anaphylatoxin, which possesses potent spasmogenic and chemotactic activity, and the C5b macromolecular cleavage product, a subunit of the membrane attack complex (MAC). Mutations in this gene cause complement component 5 deficiency, a disease characterized by recurrent bacterial infections. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2015]
Gene Name: Complement C5
Chromosome: CHR9: 123714613 -123812554
Locus: 9q33.2
SEMA4D Gene Summary
The Semaphorin 4D (SEMA4D) gene is located on chr9 :91975705-92094611 at 9q22.2.
Gene Name: Semaphorin 4D
Chromosome: CHR9: 91975705 -92094611
Locus: 9q22.2
Gene Diseases
The C5 SEMA4D Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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