C3-SUPT16H Fusion FISH Probe
The C3-SUPT16H Fusion FISH Probe is used to confirm a fusion of the C3 and SUPT16H genes. The fusion of the C3 and SUPT16H genes has been associated with Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| C3-SUPT16H-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| C3-SUPT16H-20-RERE | 20 (40 μL) | 200 μL |
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| C3-SUPT16H-20-REOR | 20 (40 μL) | 200 μL |
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| C3-SUPT16H-20-REGO | 20 (40 μL) | 200 μL |
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| C3-SUPT16H-20-REGR | 20 (40 μL) | 200 μL |
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| C3-SUPT16H-20-REAQ | 20 (40 μL) | 200 μL |
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| C3-SUPT16H-20-ORRE | 20 (40 μL) | 200 μL |
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| C3-SUPT16H-20-OROR | 20 (40 μL) | 200 μL |
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| C3-SUPT16H-20-ORGO | 20 (40 μL) | 200 μL |
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| C3-SUPT16H-20-ORAQ | 20 (40 μL) | 200 μL |
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| C3-SUPT16H-20-GORE | 20 (40 μL) | 200 μL |
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| C3-SUPT16H-20-GOOR | 20 (40 μL) | 200 μL |
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| C3-SUPT16H-20-GOGO | 20 (40 μL) | 200 μL |
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| C3-SUPT16H-20-GOGR | 20 (40 μL) | 200 μL |
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| C3-SUPT16H-20-GOAQ | 20 (40 μL) | 200 μL |
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| C3-SUPT16H-20-GRRE | 20 (40 μL) | 200 μL |
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| C3-SUPT16H-20-GROR | 20 (40 μL) | 200 μL |
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| C3-SUPT16H-20-GRGO | 20 (40 μL) | 200 μL |
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| C3-SUPT16H-20-GRGR | 20 (40 μL) | 200 μL |
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| C3-SUPT16H-20-GRAQ | 20 (40 μL) | 200 μL |
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| C3-SUPT16H-20-AQRE | 20 (40 μL) | 200 μL |
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| C3-SUPT16H-20-AQOR | 20 (40 μL) | 200 μL |
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| C3-SUPT16H-20-AQGO | 20 (40 μL) | 200 μL |
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| C3-SUPT16H-20-AQGR | 20 (40 μL) | 200 μL |
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| C3-SUPT16H-20-AQAQ | 20 (40 μL) | 200 μL |
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C3 Gene Summary
Complement component C3 plays a central role in the activation of complement system. Its activation is required for both classical and alternative complement activation pathways. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form the mature protein, which is then further processed to generate numerous peptide products. The C3a peptide, also known as the C3a anaphylatoxin, modulates inflammation and possesses antimicrobial activity. Mutations in this gene are associated with atypical hemolytic uremic syndrome and age-related macular degeneration in human patients. [provided by RefSeq, Nov 2015]
Gene Name: Complement C3
Chromosome: CHR19: 6677845 -6720662
Locus: 19p13.3
SUPT16H Gene Summary
Transcription of protein-coding genes can be reconstituted on naked DNA with only the general transcription factors and RNA polymerase II. However, this minimal system cannot transcribe DNA packaged into chromatin, indicating that accessory factors may facilitate access to DNA. One such factor, FACT (facilitates chromatin transcription), interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT is composed of an 80 kDa subunit and a 140 kDa subunit; this gene encodes the 140 kDa subunit. [provided by RefSeq, Feb 2009]
Gene Name: SPT16 Homolog, Facilitates Chromatin Remodeling Subunit
Chromosome: CHR14: 21819630 -21852425
Locus: 14q11.2
Gene Diseases
The C3 SUPT16H Fusion has been associated with the following diseases:
| Disease Name |
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| Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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