C3-SEC63 Fusion FISH Probe
The C3-SEC63 Fusion FISH Probe is used to confirm a fusion of the C3 and SEC63 genes. The fusion of the C3 and SEC63 genes has been associated with Uterine Carcinosarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| C3-SEC63-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| C3-SEC63-20-RERE | 20 (40 μL) | 200 μL |
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| C3-SEC63-20-REOR | 20 (40 μL) | 200 μL |
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| C3-SEC63-20-REGO | 20 (40 μL) | 200 μL |
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| C3-SEC63-20-REGR | 20 (40 μL) | 200 μL |
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| C3-SEC63-20-REAQ | 20 (40 μL) | 200 μL |
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| C3-SEC63-20-ORRE | 20 (40 μL) | 200 μL |
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| C3-SEC63-20-OROR | 20 (40 μL) | 200 μL |
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| C3-SEC63-20-ORGO | 20 (40 μL) | 200 μL |
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| C3-SEC63-20-ORAQ | 20 (40 μL) | 200 μL |
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| C3-SEC63-20-GORE | 20 (40 μL) | 200 μL |
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| C3-SEC63-20-GOOR | 20 (40 μL) | 200 μL |
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| C3-SEC63-20-GOGO | 20 (40 μL) | 200 μL |
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| C3-SEC63-20-GOGR | 20 (40 μL) | 200 μL |
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| C3-SEC63-20-GOAQ | 20 (40 μL) | 200 μL |
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| C3-SEC63-20-GRRE | 20 (40 μL) | 200 μL |
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| C3-SEC63-20-GROR | 20 (40 μL) | 200 μL |
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| C3-SEC63-20-GRGO | 20 (40 μL) | 200 μL |
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| C3-SEC63-20-GRGR | 20 (40 μL) | 200 μL |
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| C3-SEC63-20-GRAQ | 20 (40 μL) | 200 μL |
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| C3-SEC63-20-AQRE | 20 (40 μL) | 200 μL |
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| C3-SEC63-20-AQOR | 20 (40 μL) | 200 μL |
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| C3-SEC63-20-AQGO | 20 (40 μL) | 200 μL |
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| C3-SEC63-20-AQGR | 20 (40 μL) | 200 μL |
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| C3-SEC63-20-AQAQ | 20 (40 μL) | 200 μL |
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C3 Gene Summary
Complement component C3 plays a central role in the activation of complement system. Its activation is required for both classical and alternative complement activation pathways. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form the mature protein, which is then further processed to generate numerous peptide products. The C3a peptide, also known as the C3a anaphylatoxin, modulates inflammation and possesses antimicrobial activity. Mutations in this gene are associated with atypical hemolytic uremic syndrome and age-related macular degeneration in human patients. [provided by RefSeq, Nov 2015]
Gene Name: Complement C3
Chromosome: CHR19: 6677845 -6720662
Locus: 19p13.3
SEC63 Gene Summary
The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. The protein encoded by this gene and SEC62 protein are found to be associated with ribosome-free SEC61 complex. It is speculated that Sec61-Sec62-Sec63 may perform post-translational protein translocation into the ER. The Sec61-Sec62-Sec63 complex might also perform the backward transport of ER proteins that are subject to the ubiquitin-proteasome-dependent degradation pathway. The encoded protein is an integral membrane protein located in the rough ER. [provided by RefSeq, Jul 2008]
Gene Name: SEC63 Homolog, Protein Translocation Regulator
Chromosome: CHR6: 108188959 -108279482
Locus: 6q21
Gene Diseases
The C3 SEC63 Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Carcinosarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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