C3-ELK3 Fusion FISH Probe
The C3-ELK3 Fusion FISH Probe is used to confirm a fusion of the C3 and ELK3 genes. The fusion of the C3 and ELK3 genes has been associated with Thyroid Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| C3-ELK3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| C3-ELK3-20-RERE | 20 (40 μL) | 200 μL |
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| C3-ELK3-20-REOR | 20 (40 μL) | 200 μL |
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| C3-ELK3-20-REGO | 20 (40 μL) | 200 μL |
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| C3-ELK3-20-REGR | 20 (40 μL) | 200 μL |
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| C3-ELK3-20-REAQ | 20 (40 μL) | 200 μL |
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| C3-ELK3-20-ORRE | 20 (40 μL) | 200 μL |
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| C3-ELK3-20-OROR | 20 (40 μL) | 200 μL |
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| C3-ELK3-20-ORGO | 20 (40 μL) | 200 μL |
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| C3-ELK3-20-ORAQ | 20 (40 μL) | 200 μL |
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| C3-ELK3-20-GORE | 20 (40 μL) | 200 μL |
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| C3-ELK3-20-GOOR | 20 (40 μL) | 200 μL |
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| C3-ELK3-20-GOGO | 20 (40 μL) | 200 μL |
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| C3-ELK3-20-GOGR | 20 (40 μL) | 200 μL |
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| C3-ELK3-20-GOAQ | 20 (40 μL) | 200 μL |
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| C3-ELK3-20-GRRE | 20 (40 μL) | 200 μL |
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| C3-ELK3-20-GROR | 20 (40 μL) | 200 μL |
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| C3-ELK3-20-GRGO | 20 (40 μL) | 200 μL |
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| C3-ELK3-20-GRGR | 20 (40 μL) | 200 μL |
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| C3-ELK3-20-GRAQ | 20 (40 μL) | 200 μL |
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| C3-ELK3-20-AQRE | 20 (40 μL) | 200 μL |
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| C3-ELK3-20-AQOR | 20 (40 μL) | 200 μL |
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| C3-ELK3-20-AQGO | 20 (40 μL) | 200 μL |
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| C3-ELK3-20-AQGR | 20 (40 μL) | 200 μL |
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| C3-ELK3-20-AQAQ | 20 (40 μL) | 200 μL |
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C3 Gene Summary
Complement component C3 plays a central role in the activation of complement system. Its activation is required for both classical and alternative complement activation pathways. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form the mature protein, which is then further processed to generate numerous peptide products. The C3a peptide, also known as the C3a anaphylatoxin, modulates inflammation and possesses antimicrobial activity. Mutations in this gene are associated with atypical hemolytic uremic syndrome and age-related macular degeneration in human patients. [provided by RefSeq, Nov 2015]
Gene Name: Complement C3
Chromosome: CHR19: 6677845 -6720662
Locus: 19p13.3
ELK3 Gene Summary
This gene encodes a member of the ETS-domain transcription factor family and the ternary complex factor (TCF) subfamily. Proteins in this subfamily regulate transcription when recruited by serum response factor to bind to serum response elements. This protein is activated by signal-induced phosphorylation; studies in rodents suggest that it is a transcriptional inhibitor in the absence of Ras, but activates transcription when Ras is present. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
Gene Name: ELK3, ETS Transcription Factor
Chromosome: CHR12: 96588206 -96661606
Locus: 12q23.1
Gene Diseases
The C3 ELK3 Fusion has been associated with the following diseases:
| Disease Name |
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| Thyroid Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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