C3-DDX21 Fusion FISH Probe
The C3-DDX21 Fusion FISH Probe is used to confirm a fusion of the C3 and DDX21 genes. The fusion of the C3 and DDX21 genes has been associated with Liver Hepatocellular Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| C3-DDX21-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| C3-DDX21-20-RERE | 20 (40 μL) | 200 μL |
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| C3-DDX21-20-REOR | 20 (40 μL) | 200 μL |
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| C3-DDX21-20-REGO | 20 (40 μL) | 200 μL |
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| C3-DDX21-20-REGR | 20 (40 μL) | 200 μL |
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| C3-DDX21-20-REAQ | 20 (40 μL) | 200 μL |
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| C3-DDX21-20-ORRE | 20 (40 μL) | 200 μL |
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| C3-DDX21-20-OROR | 20 (40 μL) | 200 μL |
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| C3-DDX21-20-ORGO | 20 (40 μL) | 200 μL |
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| C3-DDX21-20-ORAQ | 20 (40 μL) | 200 μL |
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| C3-DDX21-20-GORE | 20 (40 μL) | 200 μL |
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| C3-DDX21-20-GOOR | 20 (40 μL) | 200 μL |
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| C3-DDX21-20-GOGO | 20 (40 μL) | 200 μL |
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| C3-DDX21-20-GOGR | 20 (40 μL) | 200 μL |
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| C3-DDX21-20-GOAQ | 20 (40 μL) | 200 μL |
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| C3-DDX21-20-GRRE | 20 (40 μL) | 200 μL |
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| C3-DDX21-20-GROR | 20 (40 μL) | 200 μL |
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| C3-DDX21-20-GRGO | 20 (40 μL) | 200 μL |
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| C3-DDX21-20-GRGR | 20 (40 μL) | 200 μL |
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| C3-DDX21-20-GRAQ | 20 (40 μL) | 200 μL |
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| C3-DDX21-20-AQRE | 20 (40 μL) | 200 μL |
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| C3-DDX21-20-AQOR | 20 (40 μL) | 200 μL |
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| C3-DDX21-20-AQGO | 20 (40 μL) | 200 μL |
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| C3-DDX21-20-AQGR | 20 (40 μL) | 200 μL |
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| C3-DDX21-20-AQAQ | 20 (40 μL) | 200 μL |
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C3 Gene Summary
Complement component C3 plays a central role in the activation of complement system. Its activation is required for both classical and alternative complement activation pathways. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form the mature protein, which is then further processed to generate numerous peptide products. The C3a peptide, also known as the C3a anaphylatoxin, modulates inflammation and possesses antimicrobial activity. Mutations in this gene are associated with atypical hemolytic uremic syndrome and age-related macular degeneration in human patients. [provided by RefSeq, Nov 2015]
Gene Name: Complement C3
Chromosome: CHR19: 6677845 -6720662
Locus: 19p13.3
DDX21 Gene Summary
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is an antigen recognized by autoimmune antibodies from a patient with watermelon stomach disease. This protein unwinds double-stranded RNA, folds single-stranded RNA, and may play important roles in ribosomal RNA biogenesis, RNA editing, RNA transport, and general transcription. [provided by RefSeq, Jul 2008]
Gene Name: DExD-box Helicase 21
Chromosome: CHR10: 70715891 -70744279
Locus: 10q22.1
Gene Diseases
The C3 DDX21 Fusion has been associated with the following diseases:
| Disease Name |
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| Liver Hepatocellular Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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