C2CD3-VPS37C Fusion FISH Probe
The C2CD3-VPS37C Fusion FISH Probe is used to confirm a fusion of the C2CD3 and VPS37C genes. The fusion of the C2CD3 and VPS37C genes has been associated with Rectum Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| C2CD3-VPS37C-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| C2CD3-VPS37C-20-RERE | 20 (40 μL) | 200 μL |
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| C2CD3-VPS37C-20-REOR | 20 (40 μL) | 200 μL |
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| C2CD3-VPS37C-20-REGO | 20 (40 μL) | 200 μL |
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| C2CD3-VPS37C-20-REGR | 20 (40 μL) | 200 μL |
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| C2CD3-VPS37C-20-REAQ | 20 (40 μL) | 200 μL |
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| C2CD3-VPS37C-20-ORRE | 20 (40 μL) | 200 μL |
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| C2CD3-VPS37C-20-OROR | 20 (40 μL) | 200 μL |
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| C2CD3-VPS37C-20-ORGO | 20 (40 μL) | 200 μL |
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| C2CD3-VPS37C-20-ORAQ | 20 (40 μL) | 200 μL |
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| C2CD3-VPS37C-20-GORE | 20 (40 μL) | 200 μL |
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| C2CD3-VPS37C-20-GOOR | 20 (40 μL) | 200 μL |
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| C2CD3-VPS37C-20-GOGO | 20 (40 μL) | 200 μL |
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| C2CD3-VPS37C-20-GOGR | 20 (40 μL) | 200 μL |
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| C2CD3-VPS37C-20-GOAQ | 20 (40 μL) | 200 μL |
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| C2CD3-VPS37C-20-GRRE | 20 (40 μL) | 200 μL |
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| C2CD3-VPS37C-20-GROR | 20 (40 μL) | 200 μL |
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| C2CD3-VPS37C-20-GRGO | 20 (40 μL) | 200 μL |
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| C2CD3-VPS37C-20-GRGR | 20 (40 μL) | 200 μL |
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| C2CD3-VPS37C-20-GRAQ | 20 (40 μL) | 200 μL |
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| C2CD3-VPS37C-20-AQRE | 20 (40 μL) | 200 μL |
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| C2CD3-VPS37C-20-AQOR | 20 (40 μL) | 200 μL |
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| C2CD3-VPS37C-20-AQGO | 20 (40 μL) | 200 μL |
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| C2CD3-VPS37C-20-AQGR | 20 (40 μL) | 200 μL |
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| C2CD3-VPS37C-20-AQAQ | 20 (40 μL) | 200 μL |
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C2CD3 Gene Summary
This gene encodes a protein that functions as a regulator of centriole elongation. Studies of the orthologous mouse protein show that it promotes centriolar distal appendage assembly and is also required for the recruitment of other ciliogenic proteins, including intraflagellar transport proteins. Mutations in this gene cause orofaciodigital syndrome XIV (OFD14), a ciliopathy resulting in malformations of the oral cavity, face and digits. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Nov 2014]
Gene Name: C2 Calcium Dependent Domain Containing 3
Chromosome: CHR11: 73745479 -73882064
Locus: 11q13.4
VPS37C Gene Summary
VPS37C is a subunit of ESCRT-I (endosomal sorting complex required for transport I), a complex in the class E vacuolar protein sorting (VPS) pathway required for sorting ubiquitinated transmembrane proteins into internal vesicles of multivesicular bodies (Eastman et al., 2005 [PubMed 15509564]).[supplied by OMIM, Mar 2008]
Gene Name: VPS37C, ESCRT-I Subunit
Chromosome: CHR11: 60897727 -60928916
Locus: 11q12.2
Gene Diseases
The C2CD3 VPS37C Fusion has been associated with the following diseases:
| Disease Name |
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| Rectum Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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