C2CD3-PC Fusion FISH Probe
The C2CD3-PC Fusion FISH Probe is used to confirm a fusion of the C2CD3 and PC genes. The fusion of the C2CD3 and PC genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| C2CD3-PC-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| C2CD3-PC-20-RERE | 20 (40 μL) | 200 μL |
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| C2CD3-PC-20-REOR | 20 (40 μL) | 200 μL |
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| C2CD3-PC-20-REGO | 20 (40 μL) | 200 μL |
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| C2CD3-PC-20-REGR | 20 (40 μL) | 200 μL |
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| C2CD3-PC-20-REAQ | 20 (40 μL) | 200 μL |
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| C2CD3-PC-20-ORRE | 20 (40 μL) | 200 μL |
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| C2CD3-PC-20-OROR | 20 (40 μL) | 200 μL |
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| C2CD3-PC-20-ORGO | 20 (40 μL) | 200 μL |
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| C2CD3-PC-20-ORAQ | 20 (40 μL) | 200 μL |
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| C2CD3-PC-20-GORE | 20 (40 μL) | 200 μL |
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| C2CD3-PC-20-GOOR | 20 (40 μL) | 200 μL |
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| C2CD3-PC-20-GOGO | 20 (40 μL) | 200 μL |
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| C2CD3-PC-20-GOGR | 20 (40 μL) | 200 μL |
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| C2CD3-PC-20-GOAQ | 20 (40 μL) | 200 μL |
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| C2CD3-PC-20-GRRE | 20 (40 μL) | 200 μL |
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| C2CD3-PC-20-GROR | 20 (40 μL) | 200 μL |
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| C2CD3-PC-20-GRGO | 20 (40 μL) | 200 μL |
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| C2CD3-PC-20-GRGR | 20 (40 μL) | 200 μL |
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| C2CD3-PC-20-GRAQ | 20 (40 μL) | 200 μL |
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| C2CD3-PC-20-AQRE | 20 (40 μL) | 200 μL |
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| C2CD3-PC-20-AQOR | 20 (40 μL) | 200 μL |
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| C2CD3-PC-20-AQGO | 20 (40 μL) | 200 μL |
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| C2CD3-PC-20-AQGR | 20 (40 μL) | 200 μL |
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| C2CD3-PC-20-AQAQ | 20 (40 μL) | 200 μL |
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PC Gene Summary
This gene encodes pyruvate carboxylase, which requires biotin and ATP to catalyse the carboxylation of pyruvate to oxaloacetate. The active enzyme is a homotetramer arranged in a tetrahedron which is located exclusively in the mitochondrial matrix. Pyruvate carboxylase is involved in gluconeogenesis, lipogenesis, insulin secretion and synthesis of the neurotransmitter glutamate. Mutations in this gene have been associated with pyruvate carboxylase deficiency. Alternatively spliced transcript variants with different 5' UTRs, but encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Pyruvate Carboxylase
Chromosome: CHR11: 66615996 -66725847
Locus: 11q13.2
C2CD3 Gene Summary
This gene encodes a protein that functions as a regulator of centriole elongation. Studies of the orthologous mouse protein show that it promotes centriolar distal appendage assembly and is also required for the recruitment of other ciliogenic proteins, including intraflagellar transport proteins. Mutations in this gene cause orofaciodigital syndrome XIV (OFD14), a ciliopathy resulting in malformations of the oral cavity, face and digits. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Nov 2014]
Gene Name: C2 Calcium Dependent Domain Containing 3
Chromosome: CHR11: 73745479 -73882064
Locus: 11q13.4
Gene Diseases
The C2CD3 PC Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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