C12ORF56-APPL2 Fusion FISH Probe
The C12ORF56-APPL2 Fusion FISH Probe is used to confirm a fusion of the C12ORF56 and APPL2 genes. The fusion of the C12ORF56 and APPL2 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| C12ORF56-APPL2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| C12ORF56-APPL2-20-RERE | 20 (40 μL) | 200 μL |
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| C12ORF56-APPL2-20-REOR | 20 (40 μL) | 200 μL |
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| C12ORF56-APPL2-20-REGO | 20 (40 μL) | 200 μL |
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| C12ORF56-APPL2-20-REGR | 20 (40 μL) | 200 μL |
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| C12ORF56-APPL2-20-REAQ | 20 (40 μL) | 200 μL |
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| C12ORF56-APPL2-20-ORRE | 20 (40 μL) | 200 μL |
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| C12ORF56-APPL2-20-OROR | 20 (40 μL) | 200 μL |
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| C12ORF56-APPL2-20-ORGO | 20 (40 μL) | 200 μL |
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| C12ORF56-APPL2-20-ORAQ | 20 (40 μL) | 200 μL |
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| C12ORF56-APPL2-20-GORE | 20 (40 μL) | 200 μL |
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| C12ORF56-APPL2-20-GOOR | 20 (40 μL) | 200 μL |
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| C12ORF56-APPL2-20-GOGO | 20 (40 μL) | 200 μL |
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| C12ORF56-APPL2-20-GOGR | 20 (40 μL) | 200 μL |
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| C12ORF56-APPL2-20-GOAQ | 20 (40 μL) | 200 μL |
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| C12ORF56-APPL2-20-GRRE | 20 (40 μL) | 200 μL |
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| C12ORF56-APPL2-20-GROR | 20 (40 μL) | 200 μL |
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| C12ORF56-APPL2-20-GRGO | 20 (40 μL) | 200 μL |
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| C12ORF56-APPL2-20-GRGR | 20 (40 μL) | 200 μL |
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| C12ORF56-APPL2-20-GRAQ | 20 (40 μL) | 200 μL |
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| C12ORF56-APPL2-20-AQRE | 20 (40 μL) | 200 μL |
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| C12ORF56-APPL2-20-AQOR | 20 (40 μL) | 200 μL |
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| C12ORF56-APPL2-20-AQGO | 20 (40 μL) | 200 μL |
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| C12ORF56-APPL2-20-AQGR | 20 (40 μL) | 200 μL |
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| C12ORF56-APPL2-20-AQAQ | 20 (40 μL) | 200 μL |
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APPL2 Gene Summary
The protein encoded by this gene is one of two effectors of the small GTPase RAB5A/Rab5, which are involved in a signal transduction pathway. Both effectors contain an N-terminal Bin/Amphiphysin/Rvs (BAR) domain, a central pleckstrin homology (PH) domain, and a C-terminal phosphotyrosine binding (PTB) domain, and they bind the Rab5 through the BAR domain. They are associated with endosomal membranes and can be translocated to the nucleus in response to the EGF stimulus. They interact with the NuRD/MeCP1 complex (nucleosome remodeling and deacetylase /methyl-CpG-binding protein 1 complex) and are required for efficient cell proliferation. A chromosomal aberration t(12;22)(q24.1;q13.3) involving this gene and the PSAP2 gene results in 22q13.3 deletion syndrome, also known as Phelan-McDermid syndrome. [provided by RefSeq, Oct 2011]
Gene Name: Adaptor Protein, Phosphotyrosine Interacting With PH Domain And Leucine Zipper 2
Chromosome: CHR12: 105567074 -105630008
Locus: 12q23.3
C12orf56 Gene Summary
The Chromosome 12 Open Reading Frame 56 (C12orf56) gene is located on chr12 :64660762-64784345 at 12q14.2.
Gene Name: Chromosome 12 Open Reading Frame 56
Chromosome: CHR12: 64660762 -64784345
Locus: 12q14.2
Gene Diseases
The C12ORF56 APPL2 Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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