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C12ORF51-YAP1 Fusion FISH Probe

The C12ORF51-YAP1 Fusion FISH Probe is used to confirm a fusion of the C12ORF51 and YAP1 genes. The fusion of the C12ORF51 and YAP1 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping
Download Datasheet Download FISH Protocol Download Material Safety Data Sheet

SKU Test Kits Buffer Dye Color Order Now
C12ORF51-YAP1-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
C12ORF51-YAP1-20-RERE 20 (40 μL) 200 μL
C12ORF51-YAP1-20-REOR 20 (40 μL) 200 μL
C12ORF51-YAP1-20-REGO 20 (40 μL) 200 μL
C12ORF51-YAP1-20-REGR 20 (40 μL) 200 μL
C12ORF51-YAP1-20-REAQ 20 (40 μL) 200 μL
C12ORF51-YAP1-20-ORRE 20 (40 μL) 200 μL
C12ORF51-YAP1-20-OROR 20 (40 μL) 200 μL
C12ORF51-YAP1-20-ORGO 20 (40 μL) 200 μL
C12ORF51-YAP1-20-ORAQ 20 (40 μL) 200 μL
C12ORF51-YAP1-20-GORE 20 (40 μL) 200 μL
C12ORF51-YAP1-20-GOOR 20 (40 μL) 200 μL
C12ORF51-YAP1-20-GOGO 20 (40 μL) 200 μL
C12ORF51-YAP1-20-GOGR 20 (40 μL) 200 μL
C12ORF51-YAP1-20-GOAQ 20 (40 μL) 200 μL
C12ORF51-YAP1-20-GRRE 20 (40 μL) 200 μL
C12ORF51-YAP1-20-GROR 20 (40 μL) 200 μL
C12ORF51-YAP1-20-GRGO 20 (40 μL) 200 μL
C12ORF51-YAP1-20-GRGR 20 (40 μL) 200 μL
C12ORF51-YAP1-20-GRAQ 20 (40 μL) 200 μL
C12ORF51-YAP1-20-AQRE 20 (40 μL) 200 μL
C12ORF51-YAP1-20-AQOR 20 (40 μL) 200 μL
C12ORF51-YAP1-20-AQGO 20 (40 μL) 200 μL
C12ORF51-YAP1-20-AQGR 20 (40 μL) 200 μL
C12ORF51-YAP1-20-AQAQ 20 (40 μL) 200 μL

YAP1 Gene Summary

This gene encodes a downstream nuclear effector of the Hippo signaling pathway which is involved in development, growth, repair, and homeostasis. This gene is known to play a role in the development and progression of multiple cancers as a transcriptional regulator of this signaling pathway and may function as a potential target for cancer treatment. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2013]

Gene Name: Yes Associated Protein 1

Chromosome: CHR11: 101981191 -102104154

Locus: 11q22.1

Gene Diseases

The C12ORF51 YAP1 Fusion has been associated with the following diseases:

Disease Name
Sarcoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Diagnostics of pediatric supratentorial RELA ependymomas: integration of information from histopathology, genetics, DNA methylation and imaging

Ependymoma is a tumor of the central nervous system that can exhibit fusion of the RELA gene. Diagnosing these accurately is important, and can be done with FISH, IHC, or DNA methylation. FISH analysis was performed with RELA break apart probes (RP11_58D3 and RP11_436C17/RP11_1104L6). MN1 and YAP1 break apart probes were also used in conjunction with the DNA methylation.
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Childhood supratentorial ependymomas with YAP1_MAMLD1 fusion: an entity with characteristic clinical, radiological, cytogenetic and histopathological features

Ependymoma is a tumor that arises from tissue of the nervous system. Rare cases involve a YAP1/MAMLD1 fusion that can occur in childhood. This study sought to expand on the unique clinical features of neoplasms harboring this fusion. Our YAP1 break apart probe was used to detect YAP1 gene rearrangements in several of the cases under study. It was determined that YAP1/MAMLD1 fusion ependymomas display characteristics that distinct from RELA fusion ependymomas.
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