C11ORF57-DLAT Fusion FISH Probe
The C11ORF57-DLAT Fusion FISH Probe is used to confirm a fusion of the C11ORF57 and DLAT genes. The fusion of the C11ORF57 and DLAT genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| C11ORF57-DLAT-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| C11ORF57-DLAT-20-RERE | 20 (40 μL) | 200 μL |
|
|
| C11ORF57-DLAT-20-REOR | 20 (40 μL) | 200 μL |
|
|
| C11ORF57-DLAT-20-REGO | 20 (40 μL) | 200 μL |
|
|
| C11ORF57-DLAT-20-REGR | 20 (40 μL) | 200 μL |
|
|
| C11ORF57-DLAT-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| C11ORF57-DLAT-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| C11ORF57-DLAT-20-OROR | 20 (40 μL) | 200 μL |
|
|
| C11ORF57-DLAT-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| C11ORF57-DLAT-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| C11ORF57-DLAT-20-GORE | 20 (40 μL) | 200 μL |
|
|
| C11ORF57-DLAT-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| C11ORF57-DLAT-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| C11ORF57-DLAT-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| C11ORF57-DLAT-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| C11ORF57-DLAT-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| C11ORF57-DLAT-20-GROR | 20 (40 μL) | 200 μL |
|
|
| C11ORF57-DLAT-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| C11ORF57-DLAT-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| C11ORF57-DLAT-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| C11ORF57-DLAT-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| C11ORF57-DLAT-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| C11ORF57-DLAT-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| C11ORF57-DLAT-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| C11ORF57-DLAT-20-AQAQ | 20 (40 μL) | 200 μL |
|
DLAT Gene Summary
This gene encodes component E2 of the multi-enzyme pyruvate dehydrogenase complex (PDC). PDC resides in the inner mitochondrial membrane and catalyzes the conversion of pyruvate to acetyl coenzyme A. The protein product of this gene, dihydrolipoamide acetyltransferase, accepts acetyl groups formed by the oxidative decarboxylation of pyruvate and transfers them to coenzyme A. Dihydrolipoamide acetyltransferase is the antigen for antimitochondrial antibodies. These autoantibodies are present in nearly 95% of patients with the autoimmune liver disease primary biliary cirrhosis (PBC). In PBC, activated T lymphocytes attack and destroy epithelial cells in the bile duct where this protein is abnormally distributed and overexpressed. PBC enventually leads to cirrhosis and liver failure. Mutations in this gene are also a cause of pyruvate dehydrogenase E2 deficiency which causes primary lactic acidosis in infancy and early childhood.[provided by RefSeq, Oct 2009]
Gene Name: Dihydrolipoamide S-acetyltransferase
Chromosome: CHR11: 111895537 -111935002
Locus: 11q23.1
Gene Diseases
The C11ORF57 DLAT Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|