BUB1B-PCM1 Fusion FISH Probe
The BUB1B-PCM1 Fusion FISH Probe is used to confirm a fusion of the BUB1B and PCM1 genes. The fusion of the BUB1B and PCM1 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| BUB1B-PCM1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| BUB1B-PCM1-20-RERE | 20 (40 μL) | 200 μL |
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| BUB1B-PCM1-20-REOR | 20 (40 μL) | 200 μL |
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| BUB1B-PCM1-20-REGO | 20 (40 μL) | 200 μL |
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| BUB1B-PCM1-20-REGR | 20 (40 μL) | 200 μL |
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| BUB1B-PCM1-20-REAQ | 20 (40 μL) | 200 μL |
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| BUB1B-PCM1-20-ORRE | 20 (40 μL) | 200 μL |
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| BUB1B-PCM1-20-OROR | 20 (40 μL) | 200 μL |
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| BUB1B-PCM1-20-ORGO | 20 (40 μL) | 200 μL |
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| BUB1B-PCM1-20-ORAQ | 20 (40 μL) | 200 μL |
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| BUB1B-PCM1-20-GORE | 20 (40 μL) | 200 μL |
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| BUB1B-PCM1-20-GOOR | 20 (40 μL) | 200 μL |
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| BUB1B-PCM1-20-GOGO | 20 (40 μL) | 200 μL |
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| BUB1B-PCM1-20-GOGR | 20 (40 μL) | 200 μL |
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| BUB1B-PCM1-20-GOAQ | 20 (40 μL) | 200 μL |
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| BUB1B-PCM1-20-GRRE | 20 (40 μL) | 200 μL |
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| BUB1B-PCM1-20-GROR | 20 (40 μL) | 200 μL |
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| BUB1B-PCM1-20-GRGO | 20 (40 μL) | 200 μL |
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| BUB1B-PCM1-20-GRGR | 20 (40 μL) | 200 μL |
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| BUB1B-PCM1-20-GRAQ | 20 (40 μL) | 200 μL |
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| BUB1B-PCM1-20-AQRE | 20 (40 μL) | 200 μL |
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| BUB1B-PCM1-20-AQOR | 20 (40 μL) | 200 μL |
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| BUB1B-PCM1-20-AQGO | 20 (40 μL) | 200 μL |
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| BUB1B-PCM1-20-AQGR | 20 (40 μL) | 200 μL |
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| BUB1B-PCM1-20-AQAQ | 20 (40 μL) | 200 μL |
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BUB1B Gene Summary
This gene encodes a kinase involved in spindle checkpoint function. The protein has been localized to the kinetochore and plays a role in the inhibition of the anaphase-promoting complex/cyclosome (APC/C), delaying the onset of anaphase and ensuring proper chromosome segregation. Impaired spindle checkpoint function has been found in many forms of cancer. [provided by RefSeq, Jul 2008]
Gene Name: BUB1 Mitotic Checkpoint Serine/threonine Kinase B
Chromosome: CHR15: 40453209 -40513337
Locus: 15q15.1
PCM1 Gene Summary
The protein encoded by this gene is a component of centriolar satellites, which are electron dense granules scattered around centrosomes. Inhibition studies show that this protein is essential for the correct localization of several centrosomal proteins, and for anchoring microtubules to the centrosome. Chromosomal aberrations involving this gene are associated with papillary thyroid carcinomas and a variety of hematological malignancies, including atypical chronic myeloid leukemia and T-cell lymphoma. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]
Gene Name: Pericentriolar Material 1
Chromosome: CHR8: 17780365 -17887457
Locus: 8p22
Gene Diseases
The BUB1B PCM1 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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