BTN2A1-HIST1H2BC Fusion FISH Probe
The BTN2A1-HIST1H2BC Fusion FISH Probe is used to confirm a fusion of the BTN2A1 and HIST1H2BC genes. The fusion of the BTN2A1 and HIST1H2BC genes has been associated with Kidney Renal Clear Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| BTN2A1-HIST1H2BC-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| BTN2A1-HIST1H2BC-20-RERE | 20 (40 μL) | 200 μL |
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| BTN2A1-HIST1H2BC-20-REOR | 20 (40 μL) | 200 μL |
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| BTN2A1-HIST1H2BC-20-REGO | 20 (40 μL) | 200 μL |
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| BTN2A1-HIST1H2BC-20-REGR | 20 (40 μL) | 200 μL |
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| BTN2A1-HIST1H2BC-20-REAQ | 20 (40 μL) | 200 μL |
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| BTN2A1-HIST1H2BC-20-ORRE | 20 (40 μL) | 200 μL |
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| BTN2A1-HIST1H2BC-20-OROR | 20 (40 μL) | 200 μL |
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| BTN2A1-HIST1H2BC-20-ORGO | 20 (40 μL) | 200 μL |
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| BTN2A1-HIST1H2BC-20-ORAQ | 20 (40 μL) | 200 μL |
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| BTN2A1-HIST1H2BC-20-GORE | 20 (40 μL) | 200 μL |
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| BTN2A1-HIST1H2BC-20-GOOR | 20 (40 μL) | 200 μL |
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| BTN2A1-HIST1H2BC-20-GOGO | 20 (40 μL) | 200 μL |
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| BTN2A1-HIST1H2BC-20-GOGR | 20 (40 μL) | 200 μL |
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| BTN2A1-HIST1H2BC-20-GOAQ | 20 (40 μL) | 200 μL |
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| BTN2A1-HIST1H2BC-20-GRRE | 20 (40 μL) | 200 μL |
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| BTN2A1-HIST1H2BC-20-GROR | 20 (40 μL) | 200 μL |
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| BTN2A1-HIST1H2BC-20-GRGO | 20 (40 μL) | 200 μL |
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| BTN2A1-HIST1H2BC-20-GRGR | 20 (40 μL) | 200 μL |
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| BTN2A1-HIST1H2BC-20-GRAQ | 20 (40 μL) | 200 μL |
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| BTN2A1-HIST1H2BC-20-AQRE | 20 (40 μL) | 200 μL |
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| BTN2A1-HIST1H2BC-20-AQOR | 20 (40 μL) | 200 μL |
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| BTN2A1-HIST1H2BC-20-AQGO | 20 (40 μL) | 200 μL |
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| BTN2A1-HIST1H2BC-20-AQGR | 20 (40 μL) | 200 μL |
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| BTN2A1-HIST1H2BC-20-AQAQ | 20 (40 μL) | 200 μL |
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HIST1H2BC Gene Summary
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. The protein has antibacterial and antifungal antimicrobial activity. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2B family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015]
Gene Name: Histone Cluster 1 H2B Family Member C
Chromosome: CHR6: 26123694 -26124132
Locus: 6p22.2
BTN2A1 Gene Summary
This gene encodes a member of the immunoglobulin superfamily. The gene is located in a cluster of butyrophilin-like genes in the juxta-telomeric region of the major histocompatibility complex on chromosome 6. A pseudogene of this gene has been identified in this cluster. The encoded protein is an integral plasma membrane protein involved in lipid, fatty-acid, and sterol metabolism. Alterations in this gene may be associated with several disease states including metabolic syndrome. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2013]
Gene Name: Butyrophilin Subfamily 2 Member A1
Chromosome: CHR6: 26458152 -26476849
Locus: 6p22.2
Gene Diseases
The BTN2A1 HIST1H2BC Fusion has been associated with the following diseases:
| Disease Name |
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| Kidney Renal Clear Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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