BTBD2-OAS2 Fusion FISH Probe
The BTBD2-OAS2 Fusion FISH Probe is used to confirm a fusion of the BTBD2 and OAS2 genes. The fusion of the BTBD2 and OAS2 genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| BTBD2-OAS2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| BTBD2-OAS2-20-RERE | 20 (40 μL) | 200 μL |
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| BTBD2-OAS2-20-REOR | 20 (40 μL) | 200 μL |
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| BTBD2-OAS2-20-REGO | 20 (40 μL) | 200 μL |
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| BTBD2-OAS2-20-REGR | 20 (40 μL) | 200 μL |
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| BTBD2-OAS2-20-REAQ | 20 (40 μL) | 200 μL |
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| BTBD2-OAS2-20-ORRE | 20 (40 μL) | 200 μL |
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| BTBD2-OAS2-20-OROR | 20 (40 μL) | 200 μL |
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| BTBD2-OAS2-20-ORGO | 20 (40 μL) | 200 μL |
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| BTBD2-OAS2-20-ORAQ | 20 (40 μL) | 200 μL |
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| BTBD2-OAS2-20-GORE | 20 (40 μL) | 200 μL |
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| BTBD2-OAS2-20-GOOR | 20 (40 μL) | 200 μL |
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| BTBD2-OAS2-20-GOGO | 20 (40 μL) | 200 μL |
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| BTBD2-OAS2-20-GOGR | 20 (40 μL) | 200 μL |
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| BTBD2-OAS2-20-GOAQ | 20 (40 μL) | 200 μL |
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| BTBD2-OAS2-20-GRRE | 20 (40 μL) | 200 μL |
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| BTBD2-OAS2-20-GROR | 20 (40 μL) | 200 μL |
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| BTBD2-OAS2-20-GRGO | 20 (40 μL) | 200 μL |
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| BTBD2-OAS2-20-GRGR | 20 (40 μL) | 200 μL |
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| BTBD2-OAS2-20-GRAQ | 20 (40 μL) | 200 μL |
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| BTBD2-OAS2-20-AQRE | 20 (40 μL) | 200 μL |
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| BTBD2-OAS2-20-AQOR | 20 (40 μL) | 200 μL |
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| BTBD2-OAS2-20-AQGO | 20 (40 μL) | 200 μL |
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| BTBD2-OAS2-20-AQGR | 20 (40 μL) | 200 μL |
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| BTBD2-OAS2-20-AQAQ | 20 (40 μL) | 200 μL |
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OAS2 Gene Summary
This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Gene Name: 2'-5'-oligoadenylate Synthetase 2
Chromosome: CHR12: 113416273 -113449528
Locus: 12q24.13
BTBD2 Gene Summary
The C-terminus of the protein encoded by this gene binds topoisomerase I. The N-terminus contains a proline-rich region and a BTB/POZ domain (broad-complex, Tramtrack and bric a brac/Pox virus and Zinc finger), both of which are typically involved in protein-protein interactions. Subcellularly, the protein localizes to cytoplasmic bodies. [provided by RefSeq, Jul 2008]
Gene Name: BTB Domain Containing 2
Chromosome: CHR19: 1985446 -2015702
Locus: 19p13.3
Gene Diseases
The BTBD2 OAS2 Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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