BRCA1-NF1 Fusion FISH Probe
The BRCA1-NF1 Fusion FISH Probe is used to confirm a fusion of the BRCA1 and NF1 genes. The fusion of the BRCA1 and NF1 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| BRCA1-NF1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| BRCA1-NF1-20-RERE | 20 (40 μL) | 200 μL |
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| BRCA1-NF1-20-REOR | 20 (40 μL) | 200 μL |
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| BRCA1-NF1-20-REGO | 20 (40 μL) | 200 μL |
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| BRCA1-NF1-20-REGR | 20 (40 μL) | 200 μL |
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| BRCA1-NF1-20-REAQ | 20 (40 μL) | 200 μL |
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| BRCA1-NF1-20-ORRE | 20 (40 μL) | 200 μL |
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| BRCA1-NF1-20-OROR | 20 (40 μL) | 200 μL |
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| BRCA1-NF1-20-ORGO | 20 (40 μL) | 200 μL |
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| BRCA1-NF1-20-ORAQ | 20 (40 μL) | 200 μL |
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| BRCA1-NF1-20-GORE | 20 (40 μL) | 200 μL |
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| BRCA1-NF1-20-GOOR | 20 (40 μL) | 200 μL |
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| BRCA1-NF1-20-GOGO | 20 (40 μL) | 200 μL |
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| BRCA1-NF1-20-GOGR | 20 (40 μL) | 200 μL |
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| BRCA1-NF1-20-GOAQ | 20 (40 μL) | 200 μL |
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| BRCA1-NF1-20-GRRE | 20 (40 μL) | 200 μL |
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| BRCA1-NF1-20-GROR | 20 (40 μL) | 200 μL |
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| BRCA1-NF1-20-GRGO | 20 (40 μL) | 200 μL |
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| BRCA1-NF1-20-GRGR | 20 (40 μL) | 200 μL |
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| BRCA1-NF1-20-GRAQ | 20 (40 μL) | 200 μL |
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| BRCA1-NF1-20-AQRE | 20 (40 μL) | 200 μL |
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| BRCA1-NF1-20-AQOR | 20 (40 μL) | 200 μL |
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| BRCA1-NF1-20-AQGO | 20 (40 μL) | 200 μL |
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| BRCA1-NF1-20-AQGR | 20 (40 μL) | 200 μL |
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| BRCA1-NF1-20-AQAQ | 20 (40 μL) | 200 μL |
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BRCA1 Gene Summary
This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified. [provided by RefSeq, May 2009]
Gene Name: BRCA1, DNA Repair Associated
Chromosome: CHR17: 41196311 -41277500
Locus: 17q21.31
NF1 Gene Summary
This gene product appears to function as a negative regulator of the ras signal transduction pathway. Mutations in this gene have been linked to neurofibromatosis type 1, juvenile myelomonocytic leukemia and Watson syndrome. The mRNA for this gene is subject to RNA editing (CGA>UGA->Arg1306Term) resulting in premature translation termination. Alternatively spliced transcript variants encoding different isoforms have also been described for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Neurofibromin 1
Chromosome: CHR17: 29421944 -29704695
Locus: 17q11.2
Gene Diseases
The BRCA1 NF1 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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