BRAF-SND1 Fusion FISH Probe
The BRAF-SND1 Fusion FISH Probe is used to confirm a fusion of the BRAF and SND1 genes. The fusion of the BRAF and SND1 genes has been associated with Thyroid Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| BRAF-SND1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| BRAF-SND1-20-RERE | 20 (40 μL) | 200 μL |
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| BRAF-SND1-20-REOR | 20 (40 μL) | 200 μL |
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| BRAF-SND1-20-REGO | 20 (40 μL) | 200 μL |
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| BRAF-SND1-20-REGR | 20 (40 μL) | 200 μL |
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| BRAF-SND1-20-REAQ | 20 (40 μL) | 200 μL |
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| BRAF-SND1-20-ORRE | 20 (40 μL) | 200 μL |
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| BRAF-SND1-20-OROR | 20 (40 μL) | 200 μL |
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| BRAF-SND1-20-ORGO | 20 (40 μL) | 200 μL |
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| BRAF-SND1-20-ORAQ | 20 (40 μL) | 200 μL |
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| BRAF-SND1-20-GORE | 20 (40 μL) | 200 μL |
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| BRAF-SND1-20-GOOR | 20 (40 μL) | 200 μL |
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| BRAF-SND1-20-GOGO | 20 (40 μL) | 200 μL |
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| BRAF-SND1-20-GOGR | 20 (40 μL) | 200 μL |
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| BRAF-SND1-20-GOAQ | 20 (40 μL) | 200 μL |
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| BRAF-SND1-20-GRRE | 20 (40 μL) | 200 μL |
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| BRAF-SND1-20-GROR | 20 (40 μL) | 200 μL |
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| BRAF-SND1-20-GRGO | 20 (40 μL) | 200 μL |
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| BRAF-SND1-20-GRGR | 20 (40 μL) | 200 μL |
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| BRAF-SND1-20-GRAQ | 20 (40 μL) | 200 μL |
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| BRAF-SND1-20-AQRE | 20 (40 μL) | 200 μL |
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| BRAF-SND1-20-AQOR | 20 (40 μL) | 200 μL |
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| BRAF-SND1-20-AQGO | 20 (40 μL) | 200 μL |
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| BRAF-SND1-20-AQGR | 20 (40 μL) | 200 μL |
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| BRAF-SND1-20-AQAQ | 20 (40 μL) | 200 μL |
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BRAF Gene Summary
This gene encodes a protein belonging to the RAF family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene, most commonly the V600E mutation, are the most frequently identified cancer-causing mutations in melanoma, and have been identified in various other cancers as well, including non-Hodgkin lymphoma, colorectal cancer, thyroid carcinoma, non-small cell lung carcinoma, hairy cell leukemia and adenocarcinoma of lung. Mutations in this gene are also associated with cardiofaciocutaneous, Noonan, and Costello syndromes, which exhibit overlapping phenotypes. A pseudogene of this gene has been identified on the X chromosome. [provided by RefSeq, Aug 2017]
Gene Name: B-Raf Proto-oncogene, Serine/threonine Kinase
Chromosome: CHR7: 140433812 -140624564
Locus: 7q34
SND1 Gene Summary
This gene encodes a transcriptional co-activator that interacts with the acidic domain of Epstein-Barr virus nuclear antigen 2 (EBNA 2), a transcriptional activator that is required for B-lymphocyte transformation. Other transcription factors that interact with this protein are signal transducers and activators of transcription, STATs. This protein is also thought to be essential for normal cell growth. A similar protein in mammals and other organisms is a component of the RNA-induced silencing complex (RISC). [provided by RefSeq, Jul 2016]
Gene Name: Staphylococcal Nuclease And Tudor Domain Containing 1
Chromosome: CHR7: 127292201 -127732659
Locus: 7q32.1
Gene Diseases
The BRAF SND1 Fusion has been associated with the following diseases:
| Disease Name |
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| Thyroid Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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