BMPR2-NOP58 Fusion FISH Probe
The BMPR2-NOP58 Fusion FISH Probe is used to confirm a fusion of the BMPR2 and NOP58 genes. The fusion of the BMPR2 and NOP58 genes has been associated with Uterine Carcinosarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| BMPR2-NOP58-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| BMPR2-NOP58-20-RERE | 20 (40 μL) | 200 μL |
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| BMPR2-NOP58-20-REOR | 20 (40 μL) | 200 μL |
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| BMPR2-NOP58-20-REGO | 20 (40 μL) | 200 μL |
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| BMPR2-NOP58-20-REGR | 20 (40 μL) | 200 μL |
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| BMPR2-NOP58-20-REAQ | 20 (40 μL) | 200 μL |
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| BMPR2-NOP58-20-ORRE | 20 (40 μL) | 200 μL |
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| BMPR2-NOP58-20-OROR | 20 (40 μL) | 200 μL |
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| BMPR2-NOP58-20-ORGO | 20 (40 μL) | 200 μL |
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| BMPR2-NOP58-20-ORAQ | 20 (40 μL) | 200 μL |
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| BMPR2-NOP58-20-GORE | 20 (40 μL) | 200 μL |
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| BMPR2-NOP58-20-GOOR | 20 (40 μL) | 200 μL |
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| BMPR2-NOP58-20-GOGO | 20 (40 μL) | 200 μL |
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| BMPR2-NOP58-20-GOGR | 20 (40 μL) | 200 μL |
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| BMPR2-NOP58-20-GOAQ | 20 (40 μL) | 200 μL |
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| BMPR2-NOP58-20-GRRE | 20 (40 μL) | 200 μL |
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| BMPR2-NOP58-20-GROR | 20 (40 μL) | 200 μL |
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| BMPR2-NOP58-20-GRGO | 20 (40 μL) | 200 μL |
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| BMPR2-NOP58-20-GRGR | 20 (40 μL) | 200 μL |
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| BMPR2-NOP58-20-GRAQ | 20 (40 μL) | 200 μL |
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| BMPR2-NOP58-20-AQRE | 20 (40 μL) | 200 μL |
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| BMPR2-NOP58-20-AQOR | 20 (40 μL) | 200 μL |
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| BMPR2-NOP58-20-AQGO | 20 (40 μL) | 200 μL |
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| BMPR2-NOP58-20-AQGR | 20 (40 μL) | 200 μL |
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| BMPR2-NOP58-20-AQAQ | 20 (40 μL) | 200 μL |
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BMPR2 Gene Summary
This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of two different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension, both familial and fenfluramine-associated, and with pulmonary venoocclusive disease. [provided by RefSeq, Jul 2008]
Gene Name: Bone Morphogenetic Protein Receptor Type 2
Chromosome: CHR2: 203241049 -203432474
Locus: 2q33.1-q33.2
NOP58 Gene Summary
The protein encoded by this gene is a core component of box C/D small nucleolar ribonucleoproteins. Some box C/D small nucleolar RNAs (snoRNAs), such as U3, U8, and U14, are dependent upon the encoded protein for their synthesis. This protein is SUMOylated, which is necessary for high affinity binding to snoRNAs. [provided by RefSeq, Nov 2015]
Gene Name: NOP58 Ribonucleoprotein
Chromosome: CHR2: 203130514 -203168384
Locus: 2q33.1
Gene Diseases
The BMPR2 NOP58 Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Carcinosarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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