BMPR2-ATG4B Fusion FISH Probe
The BMPR2-ATG4B Fusion FISH Probe is used to confirm a fusion of the BMPR2 and ATG4B genes. The fusion of the BMPR2 and ATG4B genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| BMPR2-ATG4B-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| BMPR2-ATG4B-20-RERE | 20 (40 μL) | 200 μL |
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| BMPR2-ATG4B-20-REOR | 20 (40 μL) | 200 μL |
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| BMPR2-ATG4B-20-REGO | 20 (40 μL) | 200 μL |
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| BMPR2-ATG4B-20-REGR | 20 (40 μL) | 200 μL |
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| BMPR2-ATG4B-20-REAQ | 20 (40 μL) | 200 μL |
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| BMPR2-ATG4B-20-ORRE | 20 (40 μL) | 200 μL |
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| BMPR2-ATG4B-20-OROR | 20 (40 μL) | 200 μL |
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| BMPR2-ATG4B-20-ORGO | 20 (40 μL) | 200 μL |
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| BMPR2-ATG4B-20-ORAQ | 20 (40 μL) | 200 μL |
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| BMPR2-ATG4B-20-GORE | 20 (40 μL) | 200 μL |
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| BMPR2-ATG4B-20-GOOR | 20 (40 μL) | 200 μL |
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| BMPR2-ATG4B-20-GOGO | 20 (40 μL) | 200 μL |
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| BMPR2-ATG4B-20-GOGR | 20 (40 μL) | 200 μL |
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| BMPR2-ATG4B-20-GOAQ | 20 (40 μL) | 200 μL |
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| BMPR2-ATG4B-20-GRRE | 20 (40 μL) | 200 μL |
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| BMPR2-ATG4B-20-GROR | 20 (40 μL) | 200 μL |
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| BMPR2-ATG4B-20-GRGO | 20 (40 μL) | 200 μL |
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| BMPR2-ATG4B-20-GRGR | 20 (40 μL) | 200 μL |
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| BMPR2-ATG4B-20-GRAQ | 20 (40 μL) | 200 μL |
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| BMPR2-ATG4B-20-AQRE | 20 (40 μL) | 200 μL |
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| BMPR2-ATG4B-20-AQOR | 20 (40 μL) | 200 μL |
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| BMPR2-ATG4B-20-AQGO | 20 (40 μL) | 200 μL |
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| BMPR2-ATG4B-20-AQGR | 20 (40 μL) | 200 μL |
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| BMPR2-ATG4B-20-AQAQ | 20 (40 μL) | 200 μL |
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BMPR2 Gene Summary
This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of two different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension, both familial and fenfluramine-associated, and with pulmonary venoocclusive disease. [provided by RefSeq, Jul 2008]
Gene Name: Bone Morphogenetic Protein Receptor Type 2
Chromosome: CHR2: 203241049 -203432474
Locus: 2q33.1-q33.2
ATG4B Gene Summary
Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Gene Name: Autophagy Related 4B Cysteine Peptidase
Chromosome: CHR2: 242577026 -242613271
Locus: 2q37.3
Gene Diseases
The BMPR2 ATG4B Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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