BMPR1B-PDLIM5 Fusion FISH Probe
The BMPR1B-PDLIM5 Fusion FISH Probe is used to confirm a fusion of the BMPR1B and PDLIM5 genes. The fusion of the BMPR1B and PDLIM5 genes has been associated with Prostate Adenocarcinoma, and Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| BMPR1B-PDLIM5-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| BMPR1B-PDLIM5-20-RERE | 20 (40 μL) | 200 μL |
|
|
| BMPR1B-PDLIM5-20-REOR | 20 (40 μL) | 200 μL |
|
|
| BMPR1B-PDLIM5-20-REGO | 20 (40 μL) | 200 μL |
|
|
| BMPR1B-PDLIM5-20-REGR | 20 (40 μL) | 200 μL |
|
|
| BMPR1B-PDLIM5-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| BMPR1B-PDLIM5-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| BMPR1B-PDLIM5-20-OROR | 20 (40 μL) | 200 μL |
|
|
| BMPR1B-PDLIM5-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| BMPR1B-PDLIM5-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| BMPR1B-PDLIM5-20-GORE | 20 (40 μL) | 200 μL |
|
|
| BMPR1B-PDLIM5-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| BMPR1B-PDLIM5-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| BMPR1B-PDLIM5-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| BMPR1B-PDLIM5-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| BMPR1B-PDLIM5-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| BMPR1B-PDLIM5-20-GROR | 20 (40 μL) | 200 μL |
|
|
| BMPR1B-PDLIM5-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| BMPR1B-PDLIM5-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| BMPR1B-PDLIM5-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| BMPR1B-PDLIM5-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| BMPR1B-PDLIM5-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| BMPR1B-PDLIM5-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| BMPR1B-PDLIM5-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| BMPR1B-PDLIM5-20-AQAQ | 20 (40 μL) | 200 μL |
|
BMPR1B Gene Summary
This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]
Gene Name: Bone Morphogenetic Protein Receptor Type 1B
Chromosome: CHR4: 95679127 -96079601
Locus: 4q22.3
PDLIM5 Gene Summary
This gene encodes a member of a family of proteins that possess a 100-amino acid PDZ domain at the N terminus and one to three LIM domains at the C-terminus. This family member functions as a scaffold protein that tethers protein kinases to the Z-disk in striated muscles. It is thought to function in cardiomyocyte expansion and in restraining postsynaptic growth of excitatory synapses. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012]
Gene Name: PDZ And LIM Domain 5
Chromosome: CHR4: 95373037 -95589377
Locus: 4q22.3
Gene Diseases
The BMPR1B PDLIM5 Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Prostate Adenocarcinoma |
| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|