BMPR1B-MCC Fusion FISH Probe
The BMPR1B-MCC Fusion FISH Probe is used to confirm a fusion of the BMPR1B and MCC genes. The fusion of the BMPR1B and MCC genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| BMPR1B-MCC-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| BMPR1B-MCC-20-RERE | 20 (40 μL) | 200 μL |
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| BMPR1B-MCC-20-REOR | 20 (40 μL) | 200 μL |
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| BMPR1B-MCC-20-REGO | 20 (40 μL) | 200 μL |
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| BMPR1B-MCC-20-REGR | 20 (40 μL) | 200 μL |
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| BMPR1B-MCC-20-REAQ | 20 (40 μL) | 200 μL |
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| BMPR1B-MCC-20-ORRE | 20 (40 μL) | 200 μL |
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| BMPR1B-MCC-20-OROR | 20 (40 μL) | 200 μL |
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| BMPR1B-MCC-20-ORGO | 20 (40 μL) | 200 μL |
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| BMPR1B-MCC-20-ORAQ | 20 (40 μL) | 200 μL |
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| BMPR1B-MCC-20-GORE | 20 (40 μL) | 200 μL |
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| BMPR1B-MCC-20-GOOR | 20 (40 μL) | 200 μL |
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| BMPR1B-MCC-20-GOGO | 20 (40 μL) | 200 μL |
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| BMPR1B-MCC-20-GOGR | 20 (40 μL) | 200 μL |
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| BMPR1B-MCC-20-GOAQ | 20 (40 μL) | 200 μL |
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| BMPR1B-MCC-20-GRRE | 20 (40 μL) | 200 μL |
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| BMPR1B-MCC-20-GROR | 20 (40 μL) | 200 μL |
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| BMPR1B-MCC-20-GRGO | 20 (40 μL) | 200 μL |
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| BMPR1B-MCC-20-GRGR | 20 (40 μL) | 200 μL |
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| BMPR1B-MCC-20-GRAQ | 20 (40 μL) | 200 μL |
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| BMPR1B-MCC-20-AQRE | 20 (40 μL) | 200 μL |
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| BMPR1B-MCC-20-AQOR | 20 (40 μL) | 200 μL |
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| BMPR1B-MCC-20-AQGO | 20 (40 μL) | 200 μL |
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| BMPR1B-MCC-20-AQGR | 20 (40 μL) | 200 μL |
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| BMPR1B-MCC-20-AQAQ | 20 (40 μL) | 200 μL |
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BMPR1B Gene Summary
This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]
Gene Name: Bone Morphogenetic Protein Receptor Type 1B
Chromosome: CHR4: 95679127 -96079601
Locus: 4q22.3
MCC Gene Summary
This gene is a candidate colorectal tumor suppressor gene that is thought to negatively regulate cell cycle progression. The orthologous gene in the mouse expresses a phosphoprotein associated with the plasma membrane and membrane organelles, and overexpression of the mouse protein inhibits entry into S phase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Mutated In Colorectal Cancers
Chromosome: CHR5: 112357795 -112824527
Locus: 5q22.2
Gene Diseases
The BMPR1B MCC Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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