BMPR1B-ETV1 Fusion FISH Probe
The BMPR1B-ETV1 Fusion FISH Probe is used to confirm a fusion of the BMPR1B and ETV1 genes. The fusion of the BMPR1B and ETV1 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| BMPR1B-ETV1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| BMPR1B-ETV1-20-RERE | 20 (40 μL) | 200 μL |
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| BMPR1B-ETV1-20-REOR | 20 (40 μL) | 200 μL |
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| BMPR1B-ETV1-20-REGO | 20 (40 μL) | 200 μL |
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| BMPR1B-ETV1-20-REGR | 20 (40 μL) | 200 μL |
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| BMPR1B-ETV1-20-REAQ | 20 (40 μL) | 200 μL |
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| BMPR1B-ETV1-20-ORRE | 20 (40 μL) | 200 μL |
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| BMPR1B-ETV1-20-OROR | 20 (40 μL) | 200 μL |
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| BMPR1B-ETV1-20-ORGO | 20 (40 μL) | 200 μL |
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| BMPR1B-ETV1-20-ORAQ | 20 (40 μL) | 200 μL |
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| BMPR1B-ETV1-20-GORE | 20 (40 μL) | 200 μL |
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| BMPR1B-ETV1-20-GOOR | 20 (40 μL) | 200 μL |
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| BMPR1B-ETV1-20-GOGO | 20 (40 μL) | 200 μL |
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| BMPR1B-ETV1-20-GOGR | 20 (40 μL) | 200 μL |
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| BMPR1B-ETV1-20-GOAQ | 20 (40 μL) | 200 μL |
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| BMPR1B-ETV1-20-GRRE | 20 (40 μL) | 200 μL |
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| BMPR1B-ETV1-20-GROR | 20 (40 μL) | 200 μL |
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| BMPR1B-ETV1-20-GRGO | 20 (40 μL) | 200 μL |
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| BMPR1B-ETV1-20-GRGR | 20 (40 μL) | 200 μL |
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| BMPR1B-ETV1-20-GRAQ | 20 (40 μL) | 200 μL |
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| BMPR1B-ETV1-20-AQRE | 20 (40 μL) | 200 μL |
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| BMPR1B-ETV1-20-AQOR | 20 (40 μL) | 200 μL |
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| BMPR1B-ETV1-20-AQGO | 20 (40 μL) | 200 μL |
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| BMPR1B-ETV1-20-AQGR | 20 (40 μL) | 200 μL |
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| BMPR1B-ETV1-20-AQAQ | 20 (40 μL) | 200 μL |
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BMPR1B Gene Summary
This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]
Gene Name: Bone Morphogenetic Protein Receptor Type 1B
Chromosome: CHR4: 95679127 -96079601
Locus: 4q22.3
ETV1 Gene Summary
This gene encodes a member of the ETS (E twenty-six) family of transcription factors. The ETS proteins regulate many target genes that modulate biological processes like cell growth, angiogenesis, migration, proliferation and differentiation. All ETS proteins contain an ETS DNA-binding domain that binds to DNA sequences containing the consensus 5'-CGGA[AT]-3'. The protein encoded by this gene contains a conserved short acidic transactivation domain (TAD) in the N-terminal region, in addition to the ETS DNA-binding domain in the C-terminal region. This gene is involved in chromosomal translocations, which result in multiple fusion proteins including EWS-ETV1 in Ewing sarcoma and at least 10 ETV1 partners (see PMID: 19657377, Table 1) in prostate cancer. In addition to chromosomal rearrangement, this gene is overexpressed in prostate cancer, melanoma and gastrointestinal stromal tumor. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2016]
Gene Name: ETS Variant 1
Chromosome: CHR7: 13930855 -14031050
Locus: 7p21.2
Gene Diseases
The BMPR1B ETV1 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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