BMP5-COL21A1 Fusion FISH Probe
The BMP5-COL21A1 Fusion FISH Probe is used to confirm a fusion of the BMP5 and COL21A1 genes. The fusion of the BMP5 and COL21A1 genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| BMP5-COL21A1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| BMP5-COL21A1-20-RERE | 20 (40 μL) | 200 μL |
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| BMP5-COL21A1-20-REOR | 20 (40 μL) | 200 μL |
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| BMP5-COL21A1-20-REGO | 20 (40 μL) | 200 μL |
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| BMP5-COL21A1-20-REGR | 20 (40 μL) | 200 μL |
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| BMP5-COL21A1-20-REAQ | 20 (40 μL) | 200 μL |
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| BMP5-COL21A1-20-ORRE | 20 (40 μL) | 200 μL |
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| BMP5-COL21A1-20-OROR | 20 (40 μL) | 200 μL |
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| BMP5-COL21A1-20-ORGO | 20 (40 μL) | 200 μL |
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| BMP5-COL21A1-20-ORAQ | 20 (40 μL) | 200 μL |
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| BMP5-COL21A1-20-GORE | 20 (40 μL) | 200 μL |
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| BMP5-COL21A1-20-GOOR | 20 (40 μL) | 200 μL |
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| BMP5-COL21A1-20-GOGO | 20 (40 μL) | 200 μL |
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| BMP5-COL21A1-20-GOGR | 20 (40 μL) | 200 μL |
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| BMP5-COL21A1-20-GOAQ | 20 (40 μL) | 200 μL |
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| BMP5-COL21A1-20-GRRE | 20 (40 μL) | 200 μL |
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| BMP5-COL21A1-20-GROR | 20 (40 μL) | 200 μL |
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| BMP5-COL21A1-20-GRGO | 20 (40 μL) | 200 μL |
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| BMP5-COL21A1-20-GRGR | 20 (40 μL) | 200 μL |
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| BMP5-COL21A1-20-GRAQ | 20 (40 μL) | 200 μL |
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| BMP5-COL21A1-20-AQRE | 20 (40 μL) | 200 μL |
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| BMP5-COL21A1-20-AQOR | 20 (40 μL) | 200 μL |
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| BMP5-COL21A1-20-AQGO | 20 (40 μL) | 200 μL |
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| BMP5-COL21A1-20-AQGR | 20 (40 μL) | 200 μL |
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| BMP5-COL21A1-20-AQAQ | 20 (40 μL) | 200 μL |
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BMP5 Gene Summary
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone and cartilage development. Polymorphisms in this gene may be associated with osteoarthritis in human patients. This gene is differentially regulated in multiple human cancers. This gene encodes distinct protein isoforms that may be similarly proteolytically processed. [provided by RefSeq, Jul 2016]
Gene Name: Bone Morphogenetic Protein 5
Chromosome: CHR6: 55620237 -55740375
Locus: 6p12.1
COL21A1 Gene Summary
This gene encodes the alpha chain of type XXI collagen, a member of the FACIT (fibril-associated collagens with interrupted helices) collagen family. Type XXI collagen is localized to tissues containing type I collagen and maintains the integrity of the extracellular matrix. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
Gene Name: Collagen Type XXI Alpha 1 Chain
Chromosome: CHR6: 55921387 -56112378
Locus: 6p12.3-p11.2
Gene Diseases
The BMP5 COL21A1 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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