BMP2-TRIB3 Fusion FISH Probe
The BMP2-TRIB3 Fusion FISH Probe is used to confirm a fusion of the BMP2 and TRIB3 genes. The fusion of the BMP2 and TRIB3 genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| BMP2-TRIB3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| BMP2-TRIB3-20-RERE | 20 (40 μL) | 200 μL |
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| BMP2-TRIB3-20-REOR | 20 (40 μL) | 200 μL |
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| BMP2-TRIB3-20-REGO | 20 (40 μL) | 200 μL |
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| BMP2-TRIB3-20-REGR | 20 (40 μL) | 200 μL |
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| BMP2-TRIB3-20-REAQ | 20 (40 μL) | 200 μL |
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| BMP2-TRIB3-20-ORRE | 20 (40 μL) | 200 μL |
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| BMP2-TRIB3-20-OROR | 20 (40 μL) | 200 μL |
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| BMP2-TRIB3-20-ORGO | 20 (40 μL) | 200 μL |
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| BMP2-TRIB3-20-ORAQ | 20 (40 μL) | 200 μL |
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| BMP2-TRIB3-20-GORE | 20 (40 μL) | 200 μL |
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| BMP2-TRIB3-20-GOOR | 20 (40 μL) | 200 μL |
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| BMP2-TRIB3-20-GOGO | 20 (40 μL) | 200 μL |
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| BMP2-TRIB3-20-GOGR | 20 (40 μL) | 200 μL |
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| BMP2-TRIB3-20-GOAQ | 20 (40 μL) | 200 μL |
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| BMP2-TRIB3-20-GRRE | 20 (40 μL) | 200 μL |
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| BMP2-TRIB3-20-GROR | 20 (40 μL) | 200 μL |
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| BMP2-TRIB3-20-GRGO | 20 (40 μL) | 200 μL |
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| BMP2-TRIB3-20-GRGR | 20 (40 μL) | 200 μL |
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| BMP2-TRIB3-20-GRAQ | 20 (40 μL) | 200 μL |
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| BMP2-TRIB3-20-AQRE | 20 (40 μL) | 200 μL |
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| BMP2-TRIB3-20-AQOR | 20 (40 μL) | 200 μL |
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| BMP2-TRIB3-20-AQGO | 20 (40 μL) | 200 μL |
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| BMP2-TRIB3-20-AQGR | 20 (40 μL) | 200 μL |
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| BMP2-TRIB3-20-AQAQ | 20 (40 μL) | 200 μL |
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BMP2 Gene Summary
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone and cartilage development. Duplication of a regulatory region downstream of this gene causes a form of brachydactyly characterized by a malformed index finger and second toe in human patients. [provided by RefSeq, Jul 2016]
Gene Name: Bone Morphogenetic Protein 2
Chromosome: CHR20: 6748744 -6760910
Locus: 20p12.3
TRIB3 Gene Summary
The protein encoded by this gene is a putative protein kinase that is induced by the transcription factor NF-kappaB. The encoded protein is a negative regulator of NF-kappaB and can also sensitize cells to TNF- and TRAIL-induced apoptosis. In addition, this protein can negatively regulate the cell survival serine-threonine kinase AKT1. Differential promoter usage and alternate splicing result in multiple transcript variants. [provided by RefSeq, Jul 2014]
Gene Name: Tribbles Pseudokinase 3
Chromosome: CHR20: 361307 -378203
Locus: 20p13
Gene Diseases
The BMP2 TRIB3 Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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