BIRC3-CCT5 Fusion FISH Probe
The BIRC3-CCT5 Fusion FISH Probe is used to confirm a fusion of the BIRC3 and CCT5 genes. The fusion of the BIRC3 and CCT5 genes has been associated with Kidney Renal Clear Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| BIRC3-CCT5-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| BIRC3-CCT5-20-RERE | 20 (40 μL) | 200 μL |
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| BIRC3-CCT5-20-REOR | 20 (40 μL) | 200 μL |
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| BIRC3-CCT5-20-REGO | 20 (40 μL) | 200 μL |
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| BIRC3-CCT5-20-REGR | 20 (40 μL) | 200 μL |
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| BIRC3-CCT5-20-REAQ | 20 (40 μL) | 200 μL |
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| BIRC3-CCT5-20-ORRE | 20 (40 μL) | 200 μL |
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| BIRC3-CCT5-20-OROR | 20 (40 μL) | 200 μL |
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| BIRC3-CCT5-20-ORGO | 20 (40 μL) | 200 μL |
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| BIRC3-CCT5-20-ORAQ | 20 (40 μL) | 200 μL |
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| BIRC3-CCT5-20-GORE | 20 (40 μL) | 200 μL |
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| BIRC3-CCT5-20-GOOR | 20 (40 μL) | 200 μL |
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| BIRC3-CCT5-20-GOGO | 20 (40 μL) | 200 μL |
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| BIRC3-CCT5-20-GOGR | 20 (40 μL) | 200 μL |
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| BIRC3-CCT5-20-GOAQ | 20 (40 μL) | 200 μL |
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| BIRC3-CCT5-20-GRRE | 20 (40 μL) | 200 μL |
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| BIRC3-CCT5-20-GROR | 20 (40 μL) | 200 μL |
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| BIRC3-CCT5-20-GRGO | 20 (40 μL) | 200 μL |
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| BIRC3-CCT5-20-GRGR | 20 (40 μL) | 200 μL |
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| BIRC3-CCT5-20-GRAQ | 20 (40 μL) | 200 μL |
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| BIRC3-CCT5-20-AQRE | 20 (40 μL) | 200 μL |
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| BIRC3-CCT5-20-AQOR | 20 (40 μL) | 200 μL |
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| BIRC3-CCT5-20-AQGO | 20 (40 μL) | 200 μL |
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| BIRC3-CCT5-20-AQGR | 20 (40 μL) | 200 μL |
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| BIRC3-CCT5-20-AQAQ | 20 (40 μL) | 200 μL |
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BIRC3 Gene Summary
This gene encodes a member of the IAP family of proteins that inhibit apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. The encoded protein inhibits apoptosis induced by serum deprivation but does not affect apoptosis resulting from exposure to menadione, a potent inducer of free radicals. It contains 3 baculovirus IAP repeats and a ring finger domain. Transcript variants encoding the same isoform have been identified. [provided by RefSeq, Aug 2011]
Gene Name: Baculoviral IAP Repeat Containing 3
Chromosome: CHR11: 102188180 -102210135
Locus: 11q22.2
CCT5 Gene Summary
The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Mutations in this gene cause hereditary sensory and autonomic neuropathy with spastic paraplegia (HSNSP). Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 5 and 13. [provided by RefSeq, Apr 2015]
Gene Name: Chaperonin Containing TCP1 Subunit 5
Chromosome: CHR5: 10250281 -10266501
Locus: 5p15.2
Gene Diseases
The BIRC3 CCT5 Fusion has been associated with the following diseases:
| Disease Name |
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| Kidney Renal Clear Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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