BIRC2-TMEM123 Fusion FISH Probe
The BIRC2-TMEM123 Fusion FISH Probe is used to confirm a fusion of the BIRC2 and TMEM123 genes. The fusion of the BIRC2 and TMEM123 genes has been associated with Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| BIRC2-TMEM123-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| BIRC2-TMEM123-20-RERE | 20 (40 μL) | 200 μL |
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| BIRC2-TMEM123-20-REOR | 20 (40 μL) | 200 μL |
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| BIRC2-TMEM123-20-REGO | 20 (40 μL) | 200 μL |
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| BIRC2-TMEM123-20-REGR | 20 (40 μL) | 200 μL |
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| BIRC2-TMEM123-20-REAQ | 20 (40 μL) | 200 μL |
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| BIRC2-TMEM123-20-ORRE | 20 (40 μL) | 200 μL |
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| BIRC2-TMEM123-20-OROR | 20 (40 μL) | 200 μL |
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| BIRC2-TMEM123-20-ORGO | 20 (40 μL) | 200 μL |
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| BIRC2-TMEM123-20-ORAQ | 20 (40 μL) | 200 μL |
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| BIRC2-TMEM123-20-GORE | 20 (40 μL) | 200 μL |
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| BIRC2-TMEM123-20-GOOR | 20 (40 μL) | 200 μL |
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| BIRC2-TMEM123-20-GOGO | 20 (40 μL) | 200 μL |
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| BIRC2-TMEM123-20-GOGR | 20 (40 μL) | 200 μL |
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| BIRC2-TMEM123-20-GOAQ | 20 (40 μL) | 200 μL |
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| BIRC2-TMEM123-20-GRRE | 20 (40 μL) | 200 μL |
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| BIRC2-TMEM123-20-GROR | 20 (40 μL) | 200 μL |
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| BIRC2-TMEM123-20-GRGO | 20 (40 μL) | 200 μL |
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| BIRC2-TMEM123-20-GRGR | 20 (40 μL) | 200 μL |
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| BIRC2-TMEM123-20-GRAQ | 20 (40 μL) | 200 μL |
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| BIRC2-TMEM123-20-AQRE | 20 (40 μL) | 200 μL |
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| BIRC2-TMEM123-20-AQOR | 20 (40 μL) | 200 μL |
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| BIRC2-TMEM123-20-AQGO | 20 (40 μL) | 200 μL |
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| BIRC2-TMEM123-20-AQGR | 20 (40 μL) | 200 μL |
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| BIRC2-TMEM123-20-AQAQ | 20 (40 μL) | 200 μL |
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BIRC2 Gene Summary
The protein encoded by this gene is a member of a family of proteins that inhibits apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. This encoded protein inhibits apoptosis induced by serum deprivation and menadione, a potent inducer of free radicals. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Gene Name: Baculoviral IAP Repeat Containing 2
Chromosome: CHR11: 102217965 -102249401
Locus: 11q22.2
TMEM123 Gene Summary
This gene encodes a highly glycosylated transmembrane protein with a high content of threonine and serine residues in its extracellular domain, similar to a broadly defined category of proteins termed mucins. Exposure of some cell types to anti-PORIMIN (pro-oncosis receptor inducing membrane injury) antibody, crosslinks this protein on the cell surface and induces a type of cell death termed oncosis. Oncosis is distinct from apoptosis and is characterized by a loss of cell membrane integrity without DNA fragmentation. This gene product is proposed to function as a cell surface receptor that mediates cell death. [provided by RefSeq, Jul 2008]
Gene Name: Transmembrane Protein 123
Chromosome: CHR11: 102267055 -102323775
Locus: 11q22.2
Gene Diseases
The BIRC2 TMEM123 Fusion has been associated with the following diseases:
| Disease Name |
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| Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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