BICD1-CDK6 Fusion FISH Probe
The BICD1-CDK6 Fusion FISH Probe is used to confirm a fusion of the BICD1 and CDK6 genes. The fusion of the BICD1 and CDK6 genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| BICD1-CDK6-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| BICD1-CDK6-20-RERE | 20 (40 μL) | 200 μL |
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| BICD1-CDK6-20-REOR | 20 (40 μL) | 200 μL |
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| BICD1-CDK6-20-REGO | 20 (40 μL) | 200 μL |
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| BICD1-CDK6-20-REGR | 20 (40 μL) | 200 μL |
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| BICD1-CDK6-20-REAQ | 20 (40 μL) | 200 μL |
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| BICD1-CDK6-20-ORRE | 20 (40 μL) | 200 μL |
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| BICD1-CDK6-20-OROR | 20 (40 μL) | 200 μL |
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| BICD1-CDK6-20-ORGO | 20 (40 μL) | 200 μL |
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| BICD1-CDK6-20-ORAQ | 20 (40 μL) | 200 μL |
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| BICD1-CDK6-20-GORE | 20 (40 μL) | 200 μL |
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| BICD1-CDK6-20-GOOR | 20 (40 μL) | 200 μL |
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| BICD1-CDK6-20-GOGO | 20 (40 μL) | 200 μL |
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| BICD1-CDK6-20-GOGR | 20 (40 μL) | 200 μL |
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| BICD1-CDK6-20-GOAQ | 20 (40 μL) | 200 μL |
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| BICD1-CDK6-20-GRRE | 20 (40 μL) | 200 μL |
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| BICD1-CDK6-20-GROR | 20 (40 μL) | 200 μL |
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| BICD1-CDK6-20-GRGO | 20 (40 μL) | 200 μL |
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| BICD1-CDK6-20-GRGR | 20 (40 μL) | 200 μL |
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| BICD1-CDK6-20-GRAQ | 20 (40 μL) | 200 μL |
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| BICD1-CDK6-20-AQRE | 20 (40 μL) | 200 μL |
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| BICD1-CDK6-20-AQOR | 20 (40 μL) | 200 μL |
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| BICD1-CDK6-20-AQGO | 20 (40 μL) | 200 μL |
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| BICD1-CDK6-20-AQGR | 20 (40 μL) | 200 μL |
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| BICD1-CDK6-20-AQAQ | 20 (40 μL) | 200 μL |
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BICD1 Gene Summary
This gene encodes an adaptor protein that belongs to the bicaudal D family of dynein cargo adaptors. The encoded protein acts as an intracellular cargo transport cofactor that regulates the microtubule-based loading of cargo onto the dynein motor complex. It also controls dynein motor activity and coordination. It has a domain architecture consisting of coiled-coil domains at the N- and C-termini that are highly conserved in other family members. Naturally occurring mutations in this gene are associated with short telomere length and emphysema. [provided by RefSeq, Aug 2017]
Gene Name: BICD Cargo Adaptor 1
Chromosome: CHR12: 32260184 -32531141
Locus: 12p11.21
CDK6 Gene Summary
The protein encoded by this gene is a member of the CMGC family of serine/threonine protein kinases. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb. Altered expression of this gene has been observed in multiple human cancers. A mutation in this gene resulting in reduced cell proliferation, and impaired cell motility and polarity, and has been identified in patients with primary microcephaly. [provided by RefSeq, Aug 2017]
Gene Name: Cyclin Dependent Kinase 6
Chromosome: CHR7: 92234234 -92465941
Locus: 7q21.2
Gene Diseases
The BICD1 CDK6 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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