BGN-TTN Fusion FISH Probe
The BGN-TTN Fusion FISH Probe is used to confirm a fusion of the BGN and TTN genes. The fusion of the BGN and TTN genes has been associated with Head And Neck Squamous Cell Carcinoma , and Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| BGN-TTN-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| BGN-TTN-20-RERE | 20 (40 μL) | 200 μL |
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| BGN-TTN-20-REOR | 20 (40 μL) | 200 μL |
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| BGN-TTN-20-REGO | 20 (40 μL) | 200 μL |
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| BGN-TTN-20-REGR | 20 (40 μL) | 200 μL |
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| BGN-TTN-20-REAQ | 20 (40 μL) | 200 μL |
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| BGN-TTN-20-ORRE | 20 (40 μL) | 200 μL |
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| BGN-TTN-20-OROR | 20 (40 μL) | 200 μL |
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| BGN-TTN-20-ORGO | 20 (40 μL) | 200 μL |
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| BGN-TTN-20-ORAQ | 20 (40 μL) | 200 μL |
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| BGN-TTN-20-GORE | 20 (40 μL) | 200 μL |
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| BGN-TTN-20-GOOR | 20 (40 μL) | 200 μL |
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| BGN-TTN-20-GOGO | 20 (40 μL) | 200 μL |
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| BGN-TTN-20-GOGR | 20 (40 μL) | 200 μL |
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| BGN-TTN-20-GOAQ | 20 (40 μL) | 200 μL |
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| BGN-TTN-20-GRRE | 20 (40 μL) | 200 μL |
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| BGN-TTN-20-GROR | 20 (40 μL) | 200 μL |
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| BGN-TTN-20-GRGO | 20 (40 μL) | 200 μL |
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| BGN-TTN-20-GRGR | 20 (40 μL) | 200 μL |
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| BGN-TTN-20-GRAQ | 20 (40 μL) | 200 μL |
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| BGN-TTN-20-AQRE | 20 (40 μL) | 200 μL |
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| BGN-TTN-20-AQOR | 20 (40 μL) | 200 μL |
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| BGN-TTN-20-AQGO | 20 (40 μL) | 200 μL |
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| BGN-TTN-20-AQGR | 20 (40 μL) | 200 μL |
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| BGN-TTN-20-AQAQ | 20 (40 μL) | 200 μL |
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BGN Gene Summary
This gene encodes a member of the small leucine-rich proteoglycan (SLRP) family of proteins. The encoded preproprotein is proteolytically processed to generate the mature protein, which plays a role in bone growth, muscle development and regeneration, and collagen fibril assembly in multiple tissues. This protein may also regulate inflammation and innate immunity. Additionally, the encoded protein may contribute to atherosclerosis and aortic valve stenosis in human patients. This gene and the related gene decorin are thought to be the result of a gene duplication. [provided by RefSeq, Nov 2015]
Gene Name: Biglycan
Chromosome: CHRX: 152760346 -152775004
Locus: Xq28
TTN Gene Summary
This gene encodes a large abundant protein of striated muscle. The product of this gene is divided into two regions, a N-terminal I-band and a C-terminal A-band. The I-band, which is the elastic part of the molecule, contains two regions of tandem immunoglobulin domains on either side of a PEVK region that is rich in proline, glutamate, valine and lysine. The A-band, which is thought to act as a protein-ruler, contains a mixture of immunoglobulin and fibronectin repeats, and possesses kinase activity. An N-terminal Z-disc region and a C-terminal M-line region bind to the Z-line and M-line of the sarcomere, respectively, so that a single titin molecule spans half the length of a sarcomere. Titin also contains binding sites for muscle associated proteins so it serves as an adhesion template for the assembly of contractile machinery in muscle cells. It has also been identified as a structural protein for chromosomes. Alternative splicing of this gene results in multiple transcript variants. Considerable variability exists in the I-band, the M-line and the Z-disc regions of titin. Variability in the I-band region contributes to the differences in elasticity of different titin isoforms and, therefore, to the differences in elasticity of different muscle types. Mutations in this gene are associated with familial hypertrophic cardiomyopathy 9, and autoantibodies to titin are produced in patients with the autoimmune disease scleroderma. [provided by RefSeq, Feb 2012]
Gene Name: Titin
Chromosome: CHR2: 179390717 -179672150
Locus: 2q31.2
Gene Diseases
The BGN TTN Fusion has been associated with the following diseases:
| Disease Name |
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| Head And Neck Squamous Cell Carcinoma |
| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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