BGN-PTP4A2 Fusion FISH Probe
The BGN-PTP4A2 Fusion FISH Probe is used to confirm a fusion of the BGN and PTP4A2 genes. The fusion of the BGN and PTP4A2 genes has been associated with Mesothelioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| BGN-PTP4A2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| BGN-PTP4A2-20-RERE | 20 (40 μL) | 200 μL |
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| BGN-PTP4A2-20-REOR | 20 (40 μL) | 200 μL |
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| BGN-PTP4A2-20-REGO | 20 (40 μL) | 200 μL |
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| BGN-PTP4A2-20-REGR | 20 (40 μL) | 200 μL |
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| BGN-PTP4A2-20-REAQ | 20 (40 μL) | 200 μL |
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| BGN-PTP4A2-20-ORRE | 20 (40 μL) | 200 μL |
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| BGN-PTP4A2-20-OROR | 20 (40 μL) | 200 μL |
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| BGN-PTP4A2-20-ORGO | 20 (40 μL) | 200 μL |
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| BGN-PTP4A2-20-ORAQ | 20 (40 μL) | 200 μL |
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| BGN-PTP4A2-20-GORE | 20 (40 μL) | 200 μL |
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| BGN-PTP4A2-20-GOOR | 20 (40 μL) | 200 μL |
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| BGN-PTP4A2-20-GOGO | 20 (40 μL) | 200 μL |
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| BGN-PTP4A2-20-GOGR | 20 (40 μL) | 200 μL |
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| BGN-PTP4A2-20-GOAQ | 20 (40 μL) | 200 μL |
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| BGN-PTP4A2-20-GRRE | 20 (40 μL) | 200 μL |
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| BGN-PTP4A2-20-GROR | 20 (40 μL) | 200 μL |
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| BGN-PTP4A2-20-GRGO | 20 (40 μL) | 200 μL |
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| BGN-PTP4A2-20-GRGR | 20 (40 μL) | 200 μL |
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| BGN-PTP4A2-20-GRAQ | 20 (40 μL) | 200 μL |
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| BGN-PTP4A2-20-AQRE | 20 (40 μL) | 200 μL |
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| BGN-PTP4A2-20-AQOR | 20 (40 μL) | 200 μL |
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| BGN-PTP4A2-20-AQGO | 20 (40 μL) | 200 μL |
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| BGN-PTP4A2-20-AQGR | 20 (40 μL) | 200 μL |
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| BGN-PTP4A2-20-AQAQ | 20 (40 μL) | 200 μL |
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BGN Gene Summary
This gene encodes a member of the small leucine-rich proteoglycan (SLRP) family of proteins. The encoded preproprotein is proteolytically processed to generate the mature protein, which plays a role in bone growth, muscle development and regeneration, and collagen fibril assembly in multiple tissues. This protein may also regulate inflammation and innate immunity. Additionally, the encoded protein may contribute to atherosclerosis and aortic valve stenosis in human patients. This gene and the related gene decorin are thought to be the result of a gene duplication. [provided by RefSeq, Nov 2015]
Gene Name: Biglycan
Chromosome: CHRX: 152760346 -152775004
Locus: Xq28
PTP4A2 Gene Summary
The protein encoded by this gene belongs to a small class of the protein tyrosine phosphatase (PTP) family. PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. PTPs in this class contain a protein tyrosine phosphatase catalytic domain and a characteristic C-terminal prenylation motif. This PTP has been shown to primarily associate with plasmic and endosomal membrane through its C-terminal prenylation. This PTP was found to interact with the beta-subunit of Rab geranylgeranyltransferase II (beta GGT II), and thus may function as a regulator of GGT II activity. Overexpression of this gene in mammalian cells conferred a transformed phenotype, which suggested its role in tumorigenesis. Alternatively spliced transcript variants have been described. Related pseudogenes exist on chromosomes 11, 12 and 17. [provided by RefSeq, Aug 2010]
Gene Name: Protein Tyrosine Phosphatase Type IVA, Member 2
Chromosome: CHR1: 32372021 -32403988
Locus: 1p35.2
Gene Diseases
The BGN PTP4A2 Fusion has been associated with the following diseases:
| Disease Name |
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| Mesothelioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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