BEST3-PTPRR Fusion FISH Probe
The BEST3-PTPRR Fusion FISH Probe is used to confirm a fusion of the BEST3 and PTPRR genes. The fusion of the BEST3 and PTPRR genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| BEST3-PTPRR-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| BEST3-PTPRR-20-RERE | 20 (40 μL) | 200 μL |
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| BEST3-PTPRR-20-REOR | 20 (40 μL) | 200 μL |
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| BEST3-PTPRR-20-REGO | 20 (40 μL) | 200 μL |
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| BEST3-PTPRR-20-REGR | 20 (40 μL) | 200 μL |
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| BEST3-PTPRR-20-REAQ | 20 (40 μL) | 200 μL |
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| BEST3-PTPRR-20-ORRE | 20 (40 μL) | 200 μL |
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| BEST3-PTPRR-20-OROR | 20 (40 μL) | 200 μL |
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| BEST3-PTPRR-20-ORGO | 20 (40 μL) | 200 μL |
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| BEST3-PTPRR-20-ORAQ | 20 (40 μL) | 200 μL |
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| BEST3-PTPRR-20-GORE | 20 (40 μL) | 200 μL |
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| BEST3-PTPRR-20-GOOR | 20 (40 μL) | 200 μL |
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| BEST3-PTPRR-20-GOGO | 20 (40 μL) | 200 μL |
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| BEST3-PTPRR-20-GOGR | 20 (40 μL) | 200 μL |
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| BEST3-PTPRR-20-GOAQ | 20 (40 μL) | 200 μL |
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| BEST3-PTPRR-20-GRRE | 20 (40 μL) | 200 μL |
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| BEST3-PTPRR-20-GROR | 20 (40 μL) | 200 μL |
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| BEST3-PTPRR-20-GRGO | 20 (40 μL) | 200 μL |
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| BEST3-PTPRR-20-GRGR | 20 (40 μL) | 200 μL |
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| BEST3-PTPRR-20-GRAQ | 20 (40 μL) | 200 μL |
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| BEST3-PTPRR-20-AQRE | 20 (40 μL) | 200 μL |
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| BEST3-PTPRR-20-AQOR | 20 (40 μL) | 200 μL |
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| BEST3-PTPRR-20-AQGO | 20 (40 μL) | 200 μL |
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| BEST3-PTPRR-20-AQGR | 20 (40 μL) | 200 μL |
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| BEST3-PTPRR-20-AQAQ | 20 (40 μL) | 200 μL |
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PTPRR Gene Summary
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracellular catalytic domain, and thus represents a receptor-type PTP. Silencing of this gene has been associated with colorectal cancer. Multiple transcript variants encoding different isoforms have been found for this gene. This gene shares a symbol (PTPRQ) with another gene, protein tyrosine phosphatase, receptor type, Q (GeneID 374462), which is also located on chromosome 12. [provided by RefSeq, May 2011]
Gene Name: Protein Tyrosine Phosphatase, Receptor Type R
Chromosome: CHR12: 71031852 -71314584
Locus: 12q15
BEST3 Gene Summary
BEST3 belongs to the bestrophin family of anion channels, which includes BEST1 (MIM 607854), the gene mutant in vitelliform macular dystrophy (VMD; MIM 153700), and 2 other BEST1-like genes, BEST2 (MIM 607335) and BEST4 (MIM 607336). Bestrophins are transmembrane (TM) proteins that share a homology region containing a high content of aromatic residues, including an invariant arg-phe-pro (RFP) motif. The bestrophin genes share a conserved gene structure, with almost identical sizes of the 8 RFP-TM domain-encoding exons and highly conserved exon-intron boundaries. Each of the 4 bestrophin genes has a unique 3-prime end of variable length (Stohr et al., 2002 [PubMed 12032738]; Tsunenari et al., 2003 [PubMed 12907679]).[supplied by OMIM, Mar 2008]
Gene Name: Bestrophin 3
Chromosome: CHR12: 70047388 -70093196
Locus: 12q15
Gene Diseases
The BEST3 PTPRR Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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