BCR-TOM1 Fusion FISH Probe
The BCR-TOM1 Fusion FISH Probe is used to confirm a fusion of the BCR and TOM1 genes. The fusion of the BCR and TOM1 genes has been associated with Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| BCR-TOM1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| BCR-TOM1-20-RERE | 20 (40 μL) | 200 μL |
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| BCR-TOM1-20-REOR | 20 (40 μL) | 200 μL |
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| BCR-TOM1-20-REGO | 20 (40 μL) | 200 μL |
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| BCR-TOM1-20-REGR | 20 (40 μL) | 200 μL |
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| BCR-TOM1-20-REAQ | 20 (40 μL) | 200 μL |
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| BCR-TOM1-20-ORRE | 20 (40 μL) | 200 μL |
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| BCR-TOM1-20-OROR | 20 (40 μL) | 200 μL |
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| BCR-TOM1-20-ORGO | 20 (40 μL) | 200 μL |
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| BCR-TOM1-20-ORAQ | 20 (40 μL) | 200 μL |
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| BCR-TOM1-20-GORE | 20 (40 μL) | 200 μL |
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| BCR-TOM1-20-GOOR | 20 (40 μL) | 200 μL |
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| BCR-TOM1-20-GOGO | 20 (40 μL) | 200 μL |
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| BCR-TOM1-20-GOGR | 20 (40 μL) | 200 μL |
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| BCR-TOM1-20-GOAQ | 20 (40 μL) | 200 μL |
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| BCR-TOM1-20-GRRE | 20 (40 μL) | 200 μL |
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| BCR-TOM1-20-GROR | 20 (40 μL) | 200 μL |
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| BCR-TOM1-20-GRGO | 20 (40 μL) | 200 μL |
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| BCR-TOM1-20-GRGR | 20 (40 μL) | 200 μL |
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| BCR-TOM1-20-GRAQ | 20 (40 μL) | 200 μL |
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| BCR-TOM1-20-AQRE | 20 (40 μL) | 200 μL |
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| BCR-TOM1-20-AQOR | 20 (40 μL) | 200 μL |
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| BCR-TOM1-20-AQGO | 20 (40 μL) | 200 μL |
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| BCR-TOM1-20-AQGR | 20 (40 μL) | 200 μL |
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| BCR-TOM1-20-AQAQ | 20 (40 μL) | 200 μL |
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BCR Gene Summary
A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: BCR, RhoGEF And GTPase Activating Protein
Chromosome: CHR22: 23522551 -23660224
Locus: 22q11.23
TOM1 Gene Summary
This gene was identified as a target of the v-myb oncogene. The encoded protein shares its N-terminal domain in common with proteins associated with vesicular trafficking at the endosome. It is recruited to the endosomes by its interaction with endofin. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
Gene Name: Target Of Myb1 Membrane Trafficking Protein
Chromosome: CHR22: 35695267 -35743987
Locus: 22q12.3
Gene Diseases
The BCR TOM1 Fusion has been associated with the following diseases:
| Disease Name |
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| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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