BCR-MYH11 Fusion FISH Probe
The BCR-MYH11 Fusion FISH Probe is used to confirm a fusion of the BCR and MYH11 genes. The fusion of the BCR and MYH11 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| BCR-MYH11-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| BCR-MYH11-20-RERE | 20 (40 μL) | 200 μL |
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| BCR-MYH11-20-REOR | 20 (40 μL) | 200 μL |
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| BCR-MYH11-20-REGO | 20 (40 μL) | 200 μL |
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| BCR-MYH11-20-REGR | 20 (40 μL) | 200 μL |
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| BCR-MYH11-20-REAQ | 20 (40 μL) | 200 μL |
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| BCR-MYH11-20-ORRE | 20 (40 μL) | 200 μL |
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| BCR-MYH11-20-OROR | 20 (40 μL) | 200 μL |
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| BCR-MYH11-20-ORGO | 20 (40 μL) | 200 μL |
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| BCR-MYH11-20-ORAQ | 20 (40 μL) | 200 μL |
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| BCR-MYH11-20-GORE | 20 (40 μL) | 200 μL |
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| BCR-MYH11-20-GOOR | 20 (40 μL) | 200 μL |
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| BCR-MYH11-20-GOGO | 20 (40 μL) | 200 μL |
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| BCR-MYH11-20-GOGR | 20 (40 μL) | 200 μL |
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| BCR-MYH11-20-GOAQ | 20 (40 μL) | 200 μL |
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| BCR-MYH11-20-GRRE | 20 (40 μL) | 200 μL |
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| BCR-MYH11-20-GROR | 20 (40 μL) | 200 μL |
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| BCR-MYH11-20-GRGO | 20 (40 μL) | 200 μL |
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| BCR-MYH11-20-GRGR | 20 (40 μL) | 200 μL |
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| BCR-MYH11-20-GRAQ | 20 (40 μL) | 200 μL |
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| BCR-MYH11-20-AQRE | 20 (40 μL) | 200 μL |
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| BCR-MYH11-20-AQOR | 20 (40 μL) | 200 μL |
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| BCR-MYH11-20-AQGO | 20 (40 μL) | 200 μL |
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| BCR-MYH11-20-AQGR | 20 (40 μL) | 200 μL |
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| BCR-MYH11-20-AQAQ | 20 (40 μL) | 200 μL |
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BCR Gene Summary
A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: BCR, RhoGEF And GTPase Activating Protein
Chromosome: CHR22: 23522551 -23660224
Locus: 22q11.23
MYH11 Gene Summary
The protein encoded by this gene is a smooth muscle myosin belonging to the myosin heavy chain family. The gene product is a subunit of a hexameric protein that consists of two heavy chain subunits and two pairs of non-identical light chain subunits. It functions as a major contractile protein, converting chemical energy into mechanical energy through the hydrolysis of ATP. The gene encoding a human ortholog of rat NUDE1 is transcribed from the reverse strand of this gene, and its 3' end overlaps with that of the latter. The pericentric inversion of chromosome 16 [inv(16)(p13q22)] produces a chimeric transcript that encodes a protein consisting of the first 165 residues from the N terminus of core-binding factor beta in a fusion with the C-terminal portion of the smooth muscle myosin heavy chain. This chromosomal rearrangement is associated with acute myeloid leukemia of the M4Eo subtype. Alternative splicing generates isoforms that are differentially expressed, with ratios changing during muscle cell maturation. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Gene Name: Myosin Heavy Chain 11
Chromosome: CHR16: 15796991 -15950887
Locus: 16p13.11
Gene Diseases
The BCR MYH11 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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